Henry Friedman
James B. Powell, Jr. Distinguished Professor of Pediatric Oncology, in the School of Medicine
Overview
Overview: Our laboratory is pursuing a comprehensive analysis of the biology and therapy of adult and childhood central nervous system malignancies, particularly high-grade medulloblastoma, glioma, and ependymoma.
Laboratory Studies: Active programs, using human adult and pediatric CNS tumor continuous cell lines, transplantable xenografts growing subcutaneously and intracranially in athymic nude mice and rats, and as well as in the subarachnoid space of the athymic nude rats, and patients tumor specimens, are defining:
1) the chemotherapeutic profile of medulloblastoma, adult and childhood glioma and ependymoma
2) mechanisms of resistance to classical bifunctional alkylators, nitrosoureas and methylators operational in malignant glioma and medulloblastoma, particularly DNA adduct and crosslink repair, O6-alkylguanine-DNA alkyltransferase elevation and DNA mismatch repair deficiency.
3) modulations designed to over come or circumvent specific mechanisms of resistance
4) the activity of signal pathway inhibitors of EGFR, m-tor and other targets
5) the therapeutic advantages of intrathecal and intratumoral drug delivery in the treatment of neoplastic meningitis and intracranial malignancies, respectively.
The results of the therapeutic studies to date have demonstrated the marked activity of alkylating agents, particularly melphalan and cyclophosphamide and the role of glutathione, AGT glutathione-S-transferase, abnormal drug transport and alterations in formation and repair of DNA-DNA crosslinks in modulating cytotoxicity of these agents. Modulations shown to be effective in enhancing alkylator activity/reversing alkylator resistance include BSO-mediated glutathione depletion, inhibition of DNA-DNA crosslink repair and inhibition of 06-alkylguanine-DNA alkyltransferase by 06-benzylguanine. Recent studies have demonstrated profound activity of temozolomide, CPT-11 topotecan, irofulven, and karenitecin as well as the combination of CPT-11 or topotecan plus BCNU or temozolomide. Successful treatment of neoplastic meningitis in nude rats with intrathecal 4-hydroperoxycyclophosphamide, melphalan, temozolomide and busulfan, and intracranial glioma in nude rats with intratumoral temozolomide has also been demonstrated. More recent studies have revealed cyclophosphamide resistance secondary to DNA interstrand crosslink repair. Additional studies have shown that cyclophosphamide crosslinks are formed at the 1,3 N7 position, serving as the basis for construction of a defined crosslink in a plasmid vector to assay for crosslink repair and allowing demonstration of the lack of a role of nucleotide excision repair. Mismatch repair deficiency has been shown as a mechanism mediating acquired methylator (procarbazine and temozolomide) resistance in an adult glioblastoma xenograft.
Clinical Studies: Clinical investigations are designed to translate laboratory programs into successful treatment for adults and children with malignant brain tumors, particularly medulloblastoma. Clinical trials for adults include phase II trials of temozolomide, ZD1839 (Iressa), karenitecin, and temozolomide plus O6-BG as well as phase I trials of topotecan plus BCNU, CPT-11 plus temozolomide, and PTK787 ± temozolomide or CCNU. Studies are in progress in children evaluating the activity CPT-11 plus temozolomide, intrathecal busulfan and cyclophosphamide/melphalan or cyclophosphamide/busulfan plus autologous bone marrow support . Extension of these studies to a larger cohort of patients is being performed nationally under the auspices of the Pediatric Brain Tumor Consortium (Henry S. Friedman -- Head of New Agents Committee).
Future studies will address the role of agents designed to decrease repair of interstrand crosslinks when given in combination with alkylating agents, as well as newer signal pathway inhibitors such as RAD001, PKI166, and DB-67.
Positions
James B. Powell, Jr. Distinguished Professor of Pediatric Oncology, in the School of Medicine in the School of Medicine
2003 School of Medicine
Professor of Neurosurgery in the School of Medicine
2003 School of Medicine
Professor of Pediatrics in the School of Medicine
2010 School of Medicine
Professor of Medicine in the School of Medicine
2018 School of Medicine
Professor of Pathology in the School of Medicine
2019 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1981 School of Medicine
Education
M.D. 1977
1977 State University of New York Upstate Medical University
Publications, Grants & Awards
- Grants (42)
- Academics Articles (839)
- Conference Pages (175)
- Book Sections (2)
National Institutes of Health
Jewish Communal Fund
National Institutes of Health
Jewish Communal Fund
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Cancer Institute
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Food and Drug Administration
The Mary Duke Biddle Foundation
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Neuro Oncology Practice
Lancet Child Adolesc Health
Advances in Radiation Oncology
Support Care Cancer
Cns Oncology
Neuro Oncology Practice
Nature Communications
Frontiers in Oncology
Ca: a Cancer Journal for Clinicians
Neuro Oncology Practice
Complement Ther Clin Pract
Cancer Res
Health Science Reports
J Neuropathol Exp Neurol
Neuro Oncology Advances
Semin Oncol Nurs
The New England Journal of Medicine
Nature Communications
J Neurooncol
Cancer Causes Control
Epilepsy & Behavior Case Reports
Clinical Cancer Research
Pathogens and Immunity
Therapeutics and Clinical Risk Management
Int J Radiat Oncol Biol Phys
Cns Oncology
Oncology (Williston Park, N.Y.)
The Journal of Biological Chemistry
Oncologist
Cancer Immunol Res
Oncoimmunology
J Neurooncol
Support Care Cancer
Nat Genet
Neuro Oncol
Nature Genetics
Pediatric Blood & Cancer
Journal of Clinical Oncology
Int J Radiat Oncol Biol Phys
Proc Natl Acad Sci U S A
Cancer Medicine
Pediatric Blood & Cancer
Br J Cancer
Cancer
J Neurooncol
Oncology Report
Oncotarget
Cancer Chemother Pharmacol
Cancer Research
Int J Radiat Oncol Biol Phys
The British Journal of Radiology
J Neurooncol
J Neurooncol
Int J Radiat Oncol Biol Phys
J Neurooncol
J Neurooncol
Neuro Oncology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology
Expert Opin Pharmacother
Journal of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncol
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
J Natl Compr Canc Netw
The British Journal of Radiology
Neuro Oncol
Cellular Therapy and Transplantation
Neuro Oncol
Journal of Clinical Oncology
Journal of Biomedical Research
Annals of Surgical Oncology
Oncology Report
Journal of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Mol Cancer Ther
British Journal of Cancer
Journal of Clinical Oncology
J Neurooncol
Cancer Chemother Pharmacol
Mol Cancer Ther
Neuro Oncology
Oncology Report
The Journal of Biological Chemistry
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Magnetic Resonance Imaging : Jmri
Neuro Oncology
British Journal of Cancer
Cancer Chemother Pharmacol
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The New England Journal of Medicine
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Chemother Pharmacol
Pediatr Blood Cancer
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Hospice & Palliative Nursing
Journal of Immunological Methods
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Pediatr Blood Cancer
Neuro Oncology
Oncology Report
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Neuro Oncology
Psychooncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Curr Cancer Drug Targets
Expert Rev Anticancer Ther
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Pediatric Blood & Cancer
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Chemotherapy and Pharmacology
Journal of Clinical Oncology
Pediatric Blood & Cancer
Therapeutics and Clinical Risk Management
Oncology Report
Oncology Report
Molecular Cancer Therapeutics
Journal of Clinical Oncology
Neuro Oncology
Molecular Carcinogenesis
Nuclear Medicine and Biology
Molecular Cancer Therapeutics
Journal of Neuro Oncology
Neuro Oncology
Psycho Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
European Journal of Cancer Supplements
European Journal of Cancer Supplements
Neurologia Medico Chirurgica
Molecular Cancer Therapeutics
Oncology Report
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging
Journal of Clinical Oncology
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Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
International Journal of Radiation Oncology, Biology, Physics
Journal of Neuro Oncology
Journal of Neuro Oncology
Nuclear Medicine and Biology
Journal of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Molecular Cancer Therapeutics
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Psycho Oncology
Current Medical Research and Opinion
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology
Bioconjugate Chemistry
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The New England Journal of Medicine
Social Science & Medicine
Pediatric Blood & Cancer
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Frontiers in Bioscience : a Journal and Virtual Library
Oncology Report
Oncology Report
Oncology Report
Molecular Cancer Therapeutics
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Oncology Report
The New England Journal of Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Molecular Cancer Therapeutics
Anticancer Research
The Journal of Biological Chemistry
American Journal of Surgery
Oncology (Williston Park, N.Y.)
European Journal of Nuclear Medicine and Molecular Imaging
Molecular Cancer Therapeutics
Journal of the American College of Surgeons
The Journal of Molecular Diagnostics
Journal of Clinical Oncology
Journal of Clinical Oncology
Molecular Cancer Therapeutics
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
The American Journal of Cardiology
The New England Journal of Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bioconjugate Chemistry
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
American Journal of Surgery
Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Chemotherapy and Pharmacology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer
Oncology (Williston Park, N.Y.)
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The Journal of Physiology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neurosurgery
Neuroimaging Clinics of North America
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Journal of Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Molecular Cancer Therapeutics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Molecular Cancer Therapeutics
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neurosurgery
Archives of Pathology & Laboratory Medicine
Neuro Oncology
Neuro Oncology
American Journal of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Treatment and Research
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Chemotherapy and Pharmacology
Neuro Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Annals of Internal Medicine
Cancer Chemotherapy and Pharmacology
Journal of Pediatric Hematology/Oncology
Journal of Personality
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The New England Journal of Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Neuropathology and Experimental Neurology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
British Journal of Cancer
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Chemotherapy and Pharmacology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Seminars in Oncology
Proceedings of the National Academy of Sciences of the United States of America
Seminars in Oncology
International Journal of Radiation Oncology, Biology, Physics
Seminars in Oncology
Acta Neuropathologica
International Journal of Radiation Oncology, Biology, Physics
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Personality
Cancer Chemotherapy and Pharmacology
Pacing and Clinical Electrophysiology : Pace
Journal of Neuro Oncology
Journal of Pediatric Hematology/Oncology
Vision Research
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Bioconjugate Chemistry
Cancer Chemotherapy and Pharmacology
Clinical Cancer Research
Psychology and Aging
European Journal of Nuclear Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The American Journal of Pathology
Journal of Investigative Medicine
Journal of Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
International Journal of Radiation Oncology, Biology, Physics
Journal of Neuroscience Methods
Cns Drugs
Laboratory Investigation
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Anticancer Research
Journal of Pediatric Hematology/Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Cancer Investigation
Journal of Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Oncology (Williston Park, N.Y.)
European Journal of Cancer
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neuroscience Methods
The American Journal of Surgical Pathology
Oncology (Williston Park, N.Y.)
Oncology (Williston Park, N.Y.)
Medical and Pediatric Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Laboratory Investigation
Neurosurgical Focus
Pediatric Neurosurgery
Medical and Pediatric Oncology
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Cancer Research
Clinical Chemistry
Cancer Genetics and Cytogenetics
Journal of Personality and Social Psychology
Cancer Research
Clinical Nuclear Medicine
Journal of Medicinal Chemistry
Archives of Pathology & Laboratory Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Medical and Pediatric Oncology
Cancer Research
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Annals of the New York Academy of Sciences
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of the Royal Society of Medicine
Nuclear Medicine and Biology
Medical and Pediatric Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Medical and Pediatric Oncology
The New England Journal of Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
British Journal of Cancer
Journal of Neuropathology and Experimental Neurology
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Journal of Medicinal Chemistry
Biophysical Journal
Medical and Pediatric Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Epidemiology
Journal of Neuro Oncology
Genes, Chromosomes & Cancer
Cancer Chemotherapy and Pharmacology
Journal of Neuro Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Proceedings of the National Academy of Sciences of the United States of America
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Pediatric Radiology
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research
Cancer Research
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
American Journal of Public Health
Medical and Pediatric Oncology
Cancer Research
Medical and Pediatric Oncology
Medical and Pediatric Oncology
British Journal of Cancer
Ajnr. American Journal of Neuroradiology
Medical and Pediatric Oncology
Journal of Personality and Social Psychology
Proceedings of the National Academy of Sciences of the United States of America
Psychology and Aging
Alcoholism, Clinical and Experimental Research
American Psychologist
The New England Journal of Medicine
Journal of Neuro Oncology
Pediatric Neurosurgery
Journal of Neuro Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Journal of Neuro Oncology
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Journal of Neuro Oncology
Journal of Neuro Oncology
Lancet (London, England)
Cancer Research
Physical Review D
American Journal of Public Health
Journal of the National Cancer Institute
Journal of the National Cancer Institute
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ajnr. American Journal of Neuroradiology
Cancer Research
Ajr. American Journal of Roentgenology
The New England Journal of Medicine
Lancet (London, England)
Journal of the National Cancer Institute
Laboratory Investigation
Medical and Pediatric Oncology
Pediatric Neurosurgery
Cancer Practice
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Cancer Chemotherapy and Pharmacology
Medical and Pediatric Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Clinical Neuropathology
Medical and Pediatric Oncology
Cancer
Nuclear Medicine and Biology
Surgical Neurology
International Journal of Radiation Oncology, Biology, Physics
The New England Journal of Medicine
Journal of Neurosurgery
Ajr. American Journal of Roentgenology
The American Journal of Pediatric Hematology/Oncology
Cardiovascular Research
Journal of Personality and Social Psychology
The New England Journal of Medicine
Cancer Research
Ajr. American Journal of Roentgenology
Journal of Neuropathology and Experimental Neurology
Cancer Research
Cancer Research
Journal of Computer Assisted Tomography
Advances in Enzyme Regulation
Medical and Pediatric Oncology
Medical and Pediatric Oncology
Cancer Chemotherapy and Pharmacology
Journal of Computer Assisted Tomography
Cancer Chemotherapy and Pharmacology
Journal of the National Cancer Institute
Hospital and Community Psychiatry
American Journal of Ophthalmology
American Journal of Ophthalmology
Cancer Research
Cancer Research
Pediatric Infectious Disease Journal
The Journal of Pediatrics
Alcoholism, Clinical and Experimental Research
Journal of Child Neurology
American Journal of Ophthalmology
Oncology (Williston Park, N.Y.)
Cancer Research
Critical Reviews in Oncology/Hematology
The New England Journal of Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Radiation Research
Medical and Pediatric Oncology
Pediatric Radiology
Journal of Computer Assisted Tomography
Ajnr. American Journal of Neuroradiology
International Journal of Radiation Oncology, Biology, Physics
Cancer Chemotherapy and Pharmacology
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
International Journal of Radiation Oncology, Biology, Physics
Journal of Personality and Social Psychology
Cancer Research
Biochemical and Biophysical Research Communications
Cancer Research
Journal of Neuro Oncology
American Journal of Ophthalmology
Laboratory Investigation
Neurologic Clinics
The Journal of Pharmacology and Experimental Therapeutics
Pediatric Clinics of North America
The New England Journal of Medicine
Biochimica Et Biophysica Acta
Ajnr. American Journal of Neuroradiology
The American Journal of Pediatric Hematology/Oncology
Medical and Pediatric Oncology
Medical and Pediatric Oncology
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Invasion & Metastasis
Cancer Research
Pediatric Infectious Disease Journal
Proceedings of the National Academy of Sciences of the United States of America
Cancer Research
Journal of Neurosurgery
Journal of Neuropathology and Experimental Neurology
Cancer Research
Journal of Neurosurgery
Cancer Research
Cancer Research
Cancer Research
Neuropathology and Applied Neurobiology
Cancer Research
International Journal of Cell Cloning
Nutrition and Cancer
Ajnr. American Journal of Neuroradiology
Ajnr. American Journal of Neuroradiology
Medical and Pediatric Oncology
Ajnr. American Journal of Neuroradiology
Journal of General Internal Medicine
Medical and Pediatric Oncology
Monographs in Pathology
Cardiovascular Drugs and Therapy
The New England Journal of Medicine
The Journal of Pediatrics
Proceedings of the National Academy of Sciences of the United States of America
Cancer Genetics and Cytogenetics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Pediatric Surgery
Journal of the National Cancer Institute
New York State Journal of Medicine
Journal of Neurosurgery
Journal of Neuropathology and Experimental Neurology
Medical and Pediatric Oncology
Acta Neuropathologica
Journal of Neurosurgery
Biochemical Pharmacology
Psychological Bulletin
Cardiovascular Drugs and Therapy
Cancer Research
Cancer Research
Ajnr. American Journal of Neuroradiology
Cancer Research
Pediatric Infectious Disease Journal
Cancer Research
Journal of Neuropathology and Experimental Neurology
Journal of Neuropathology and Experimental Neurology
The Journal of Pediatrics
Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
The American Journal of Pathology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Genetics and Cytogenetics
Medical and Pediatric Oncology
Catheterization and Cardiovascular Diagnosis
British Journal of Neurosurgery
The American Journal of Medicine
The American Journal of Medicine
Alcoholism, Clinical and Experimental Research
Journal of Personality and Social Psychology
Cancer Treatment Reports
The American Journal of Medicine
American Psychologist
Psychological Bulletin
Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The American Journal of Pathology
Journal of Neuro Oncology
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Pediatric Neuroscience
Medical and Pediatric Oncology
The Canadian Journal of Cardiology
Pediatric Hematology and Oncology
The American Journal of Pediatric Hematology/Oncology
The American Journal of Medicine
American Journal of Ophthalmology
Febs Letters
Cancer Genetics and Cytogenetics
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Neurosurgery
The American Journal of Cardiology
Journal of Personality and Social Psychology
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Journal of Neuro Oncology
Journal of Neuro Oncology
Cancer Research
Pediatric Hematology and Oncology
The American Journal of Pediatric Hematology/Oncology
Acta Neuropathologica
Cancer Treatment Reports
Neurologic Clinics
Journal of Neuropathology and Experimental Neurology
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Journal of Neurochemistry
Cancer Research
Cancer Research
American Journal of Diseases of Children (1960)
Journal of Personality and Social Psychology
Journal of Neuropathology and Experimental Neurology
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Cancer Research
Proceedings of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research
Alcoholism, Clinical and Experimental Research
Comprehensive Therapy
Journal of the American College of Cardiology
Jama
The Journal of Pediatrics
International Journal of Cardiology
American Journal of Veterinary Research
Cancer Research
Journal of Neuropathology and Experimental Neurology
Clinical Pediatrics
Journal of Neuro Oncology
Proceedings of the American Association for Cancer Research
Journal of Neuro Oncology
Journal of Neuro Oncology
Progress in Experimental Tumor Research
Journal of Cardiovascular Pharmacology
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Clinical Nephrology
Journal of Neuropathology and Experimental Neurology
American Heart Journal
The New England Journal of Medicine
The Journal of Pediatrics
Proceedings of the American Association for Cancer Research
Pediatric Research
Annals of Neurology
Proceedings of the American Association for Cancer Research
Lancet (London, England)
Clinical Nephrology
Clinical Research
The American Journal of Cardiology
Cardiovascular Research
Angiology
Circulation
Proceedings of the Clinical Dialysis and Transplant Forum
British Heart Journal
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
European Journal of Cardiology
The Journal of Thoracic and Cardiovascular Surgery
The American Journal of Physiology
Dental Laboratory Review
The American Journal of Cardiology
European Journal of Cardiology
Journal of Personality and Social Psychology
Journal of Electrocardiology
Clinical Nephrology
British Heart Journal
American Journal of Clinical Pathology
Clinica Chimica Acta; International Journal of Clinical Chemistry
The Journal of Clinical Endocrinology and Metabolism
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neurology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
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Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
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Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
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