Hui-Kuan Lin
Professor in Pathology
Overview
The research interest in Dr. Lin lab is to understand oncogenic networks between oncogenes and tumor suppressor genes, dissect the regulatory mechanisms underlying the crosstalk between ageing and cancer, to unravel the role of posttranslational modifications (PTMs) such as ubiquitination and metabolism in diverse molecular and biological processes important for cancer progression and metastasis, cancer stem regulation, cancer immunity and drug resistance by using biochemical and molecular approaches along with and genetic mouse models, and finally to develop small molecule inhibitors and antibodies targeting critical oncogenic signaling and metabolic vulnerabilities for cancer treatment. His research goals aim to not only reveal fundamental insights and concepts for cancer biology and cancer immunity, but also develop novel paradigms and therapeutic strategies for targeting human cancer and overcoming drug resistance.
Research interests include:
- Crosstalk between oncogenic and tumor suppressor networks
- Posttranslational modifications in signaling and cancer
- Cancer progression and metastasis
- Biology of normal and cancer stem cells
- Metabolism in cancer and ageing
Positions
Professor in Pathology in the School of Medicine
2023 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2023 School of Medicine
Education
Ph.D. 2002
2002 University of Rochester
Publications, Grants & Awards
- Grants (4)
- Awards (10)
- Academics Articles (37)
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of Texas Health Science Center at San Antonio
School of Pharmacy, National Taiwan University
Academia Sinica
American Association for the Advancement of Science
Wake Forest University School Of Medicine
Wake Forest University School Of Medicine
The University of Texas MD Anderson Cancer Center
Society of Chinese Bioscientists in US
The University of Texas MD Anderson Cancer Center
Department of Defense
The University of Texas MD Anderson Cancer Center
Star Protocols
Cell Reports
Semin Cancer Biol
Seminars in Cancer Biology
J Clin Invest
Mol Cell
Cell Stress
Semin Cancer Biol
Cell Discovery
Nat Cell Biol
Nature Communications
Cell Discovery
Nature Immunology
Nature Communications
Nature Cell Biology
Nature Communications
Molecular Cell
Cell Research
Science Signaling
Nature Medicine
Molecular Cell
Science (New York, N.Y.)
Nature Cell Biology
Science (New York, N.Y.)
Nature Cell Biology