Jiyong Hong
Professor of Chemistry
Overview
Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology. We synthesize biologically interesting natural products and screen small molecule libraries to identify modulators of biological processes. Then, we explore their modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addition, we design and develop unique and efficient synthetic strategies that will allow rapid access to molecular complexity and structural diversity. Through multidisciplinary approaches, including organic synthesis, molecular biology, and cell biology, the cellular components and molecular events that embody cancer, immune response, and GPCR signaling have systematically been explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.
- Synthesis of Natural Products and Study of Mode of Action: We synthesize biologically interesting natural products and explore the modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. Completed target molecules include largazole (a marine natural product with HDAC inhibitory activity), brasilibactin A (a cytotoxic siderophore), manassantins A and B (natural products with anti-HIF-1 activity), and subglutinols A and B (natural products with immunosuppressive activity).
- Development of Novel Synthetic Methodology: We design and develop unique and efficient synthetic strategies which will allow rapid access to molecular complexity and structural diversity. A specific area of interest includes the development of novel methods for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydropyrans.
- Screen of Small Molecule Libraries for Identification of Small Molecule Modulators of Biological Processes: With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. We are interested in identification of modulators of biological processes, including drug abuse and neurodegenerative diseases.
Through multidisciplinary approaches, the cellular components and molecular events that embody cancer, immune response, and neurodegenerative diseases are systematically explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.
Positions
Professor of Chemistry in the Trinity College of Arts & Sciences
2017 Trinity College of Arts & Sciences
Associate Chair of Chemistry in the Trinity College of Arts & Sciences
2019 Trinity College of Arts & Sciences
Associate Professor of Pharmacology and Cancer Biology in the School of Medicine
2013 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2005 School of Medicine
Education
B.S. 1993
1993 Seoul National University (South Korea)
M.S. 1995
1995 Seoul National University (South Korea)
Ph.D. 2001
2001 The Scripps Research Institute
Publications, Grants & Awards
- Grants (21)
- Academics Articles (93)
- Conference Pages (12)
- Book Sections (1)
Washington University in St. Louis
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
D5 Therapeutics, Inc
National Institutes of Health
American Heart Association
National Institutes of Health
National Institutes of Health
Department of Education
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Defense
National Science Foundation
National Institutes of Health
National Institutes of Health
National Institutes of Health
Chemmedchem
Nar Cancer
Frontiers in Medicine
Frontiers in Medicine
Tetrahedron Letters
Proc Natl Acad Sci U S A
Journal of Medicinal Chemistry
Investigative Opthalmology & Visual Science
Proc Natl Acad Sci U S A
European Journal of Organic Chemistry
Biochemistry
Journal of Medicinal Chemistry
Nature Communications
Chemistry (Weinheim an Der Bergstrasse, Germany)
Acs Infectious Diseases
Chemmedchem
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry
Chemistry (Weinheim an Der Bergstrasse, Germany)
J Immunol Methods
Natural Product Reports
J Proteome Res
Journal of Medicinal Chemistry
Tetrahedron Letters
Biochemical and Biophysical Research Communications
Current Topics in Medicinal Chemistry
Chemistry (Weinheim an Der Bergstrasse, Germany)
Bioorganic & Medicinal Chemistry Letters
Acs Medicinal Chemistry Letters
Acs Medicinal Chemistry Letters
Organic Letters
Marine Drugs
Journal of the American Society for Mass Spectrometry
Science (New York, N.Y.)
Acs Chemical Biology
Acs Medicinal Chemistry Letters
Angewandte Chemie International Edition
Natural Product Reports
Organic Letters
Current Opinion in Chemical Biology
Organic Letters
Metallomics : Integrated Biometal Science
Eur. J. Org. Chem.
Tetrahedron Lett.
ACS Med. Chem. Lett.
The Journal of Pharmacology and Experimental Therapeutics
Chemistry, an Asian Journal
Bioorg Med Chem Lett
Future Medicinal Chemistry
Bioorganic & Medicinal Chemistry
Angewandte Chemie International Edition
Journal of the American Chemical Society
Journal of the American Chemical Society
Organic Letters
Angewandte Chemie International Edition
Tetrahedron Letters
Chembiochem : a European Journal of Chemical Biology
American Chemical Society Chemical Biology
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Organic Chemistry
Journal of the American Chemical Society
Journal of the American Chemical Society
Journal of the American Chemical Society
Biophysical Journal
Biophysical Journal
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Biophysical Journal
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Abstracts of Papers of the American Chemical Society
Stabilizing Dynamics: Constructing Economic Knowledge (Japanese edition)
Offices & Contact
Durham, NC
27708 Box 90346
Durham, NC
27708-0347