
John Strickler
Professor of MedicineOverview
John Strickler, MD is a Professor of Medicine in the Division of Medical Oncology, where he is Co-Leader for the Precision Cancer Medicine and Investigational Therapeutics Program at the Duke Cancer Institute, Leader of the Molecular Tumor Board, and Associate Director of Clinical Research – GI Oncology. Dr. Strickler’s clinic specializes on the treatment of gastrointestinal malignancies, with a particular emphasis on gastroesophageal, pancreatic, and colorectal cancers. His research focuses on precision cancer medicine: identification of biomarkers that predict sensitivity or resistance to targeted therapies and immunotherapy. He has designed and executed clinical trials that test novel therapies and innovative therapeutic strategies. He was Principal Investigator on an investigator sponsored trial that led to the first FDA-approved therapy for HER2+ metastatic colorectal cancer. He has first-author publications in several high impact factor medical journals, including the New England Journal of Medicine, Clinical Cancer Research, Cancer Discovery, Journal of Clinical Oncology, and Lancet Oncology. Nationally, he has served as a member of the American Society of Clinical Oncology (ASCO) Treatment Guidelines Committee for Advanced Colon Cancer.
Positions
Professor of Medicine in the School of Medicine
2024 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2008 School of Medicine
Education
M.D. 2005
2005 The University of Chicago
Residency, MEDICINE
2008 University of Washington
Fellowship in Hematology-Oncology, MEDICINE
2011 Duke University, School of Medicine
Clinical Trials
MOUNTAINEER-03 (Colorectal Cancer)
ABBV-400 in Select Advanced Solid Tumor Indications
Study drug RMC-9805 for patients with KRAS G12D solid tumors (RMC-9805-001)
Study drug QTX3034 for patients with KRAS G12D solid tumors (QTX3034-001)
Perioperative dostarlimab vs standard of care for resectable colon cancer (219606) (AZUR)
Amgen2021: Advanced Solid Tumors with KRAS p.G12C Mutation
APL-5125 (Gastrointestinal Cancers)
EAY191 (ComboMATCH)
RMC-6236 (Unresectable or Metastatic Colorectal Cancer or Pancreatic Cancer)
RMC-6236 + cetuximab for colorectal or pancreatic cancer (RMC-GI-102_B)
RMC-6236 + gemcitabine and nab-paclitaxel for pancreatic cancer (RMC-GI-102_C)
Study drug QTX3046 for KRAS G12D mutated advanced solid tumors
ABBV-400 + fluororuracil, folinic acid, and bevacizumab for colorectal cancer (M24-311)
LY3962673 for KRAS G12D-mutated solid tumors
Pan-KRAS Inhibitor LY4066434 +/- SOC drugs in KRAS Mutant Solid Tumors (J5Q-OX-JRDA)
Study drug QTX3544 for participants with KRAS G12V solid tumors (QTX3544-201)
Publications, Grants & Awards
- Grants (65)
- Academics Articles (110)
- Conference Pages (141)
- Book Sections (2)
Quanta Therapeutics, Inc.
Lilly USA, LLC
Lilly USA, LLC
Quanta Therapeutics, Inc.
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710