Li Lan
Instructor in the Department of Molecular Genetics and Microbiology
Overview
The Lan Lab is dedicated to researching how cancer cells respond to DNA damage through DNA repair mechanisms and developing innovative strategies to target these pathways in cancer therapy. Our significant contributions include uncovering the critical role of PARP in DNA repair, leading to successful applications of PARP inhibitors in the treatment of breast, ovarian, and other types of cancer. We study how DNA responds to oxidative damage at specific chromosomal locations, significantly advancing our understanding of DNA damage response in different chromosomal environments. Furthermore, our recent investigations have revealed a novel mRNA and R-loop-dependent DNA repair pathway that acts as a protective mechanism for the transcribed regions of the genome, introducing a new paradigm in the field of DNA repair research.
Some of the research interests of the Lan Lab:
- Unraveling the underlying mechanisms of mRNA and R-loop-dependent DNA repair (RDDR) in cancer and developing targeted therapies. We actively investigate the molecular mechanisms of the RDDR pathway, including its regulators. We study how the pathway is processed coupling with DNA replication and chromatin remodeling. We employ screening platforms to monitor the RDDR pathway and the function of RDDR proteins, with the goal of developing inhibitors that disrupt RDDR in cancer cells. We try to identify RDDR biomarkers for patient stratification and predict the response to RDDR-targeted therapy. Additionally, we explore its potential applications in gene editing. Our research spans from basic science to translation, with a focus on the potential of mRNA-modifying enzymes as therapeutic targets for treating cancers exhibiting increased genome instability.
- Investigating the response of telomeres to oxidative damage in cancer and exploiting vulnerabilities in cancer cells. By comprehending how cancer cells respond to oxidative damage at telomeres through mechanisms such as telomerase, alternative lengthening of telomeres, and mRNA and R-loop-mediated repair pathways, our goal is to selectively eliminate cancer cells experiencing oxidative stress.
- Exploring the interplay between DNA damage response and immune response in cancer. Our investigations have shed light on the role of the DNA sensor cGAS in triggering the STING-dependent interferon response, subsequently modulating the tumor microenvironment to enhance anti-tumor immunity. Currently, we are examining how DNA damage and R-loops regulate the functions of cGAS in cancer cells. Through our mechanistic studies, we aim to provide a molecular basis for enhancing immune checkpoint blockade-mediated therapy by modulating specific cGAS functions in combination with RDDR targeted therapy.
Overall, the research conducted by the Lan Lab strives to advance our understanding of DNA repair processes in cancer and the role of RNA and R-loops in these processes. We are dedicated to translating our findings into innovative therapeutic strategies that have the potential to revolutionize cancer treatment and improve patient outcomes.
Positions
Instructor in the Department of Molecular Genetics and Microbiology in the School of Medicine
2023 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2023 School of Medicine
Education
C. 2005
2005 Tohoku University (Japan)
Publications, Grants & Awards
- Grants (1)
- Academics Articles (213)
- Conference Pages (30)
- Book Sections (2)
National Institutes of Health
Nature Communications
Journal of Medical Imaging (Bellingham, Wash.)
Scientific Reports
Frontiers in Oncology
Journal of Rare Earths
Journal of Rare Earths
Nat Rev Mol Cell Biol
Russian Journal of Physical Chemistry A
Nat Rev Mol Cell Biol
Journal of Medical Imaging (Bellingham, Wash.)
Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering
Canadian Journal of Chemical Engineering
Proc Natl Acad Sci U S A
Arabian Journal of Chemistry
Int J Food Sci Nutr
Risk Management and Healthcare Policy
Cost Effectiveness and Resource Allocation : C/E
Annals of Surgical Oncology
J Digit Imaging
Nanomaterials (Basel, Switzerland)
Chinese Journal of Applied Clinical Pediatrics
Journal of Gastroenterology and Hepatology
Frontiers in Pharmacology
Mol Cell
Chinese Journal of Applied Clinical Pediatrics
Nucleic Acids Res
Nature Communications
Febs Letters
Cell & Bioscience
Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering
Nucleic Acids Res
Canadian Journal of Chemical Engineering
International Journal of Polymeric Materials and Polymeric Biomaterials
Journal of Industrial and Engineering Chemistry
Cell Reports
Cell Reports
Quantitative Imaging in Medicine and Surgery
Scientific Reports
Nature Communications
Wuji Cailiao Xuebao/Journal of Inorganic Materials
Materials & Design
Asia Pac J Clin Oncol
Journal of Industrial and Engineering Chemistry
Russian Journal of Physical Chemistry A
Journal of the Taiwan Institute of Chemical Engineers
Scientific Reports
Materials Research Bulletin
Journal of Industrial and Engineering Chemistry
Environ Res
The Journal of Biological Chemistry
Applied Surface Science
Journal of Medical Imaging (Bellingham, Wash.)
J Cancer Res Ther
Annals of Nutrition & Metabolism
Dna Repair (Amst)
Sci China Life Sci
Sci China Life Sci
Hypertension
Journal of Materials Science
Disaster Med Public Health Prep
Journal of Materials Science
Journal of Materials Science
Nucleic Acids Res
Nucleic Acids Res
Int J Occup Environ Med
Environ Sci Pollut Res Int
Mol Cell
Chinese Journal of Endemiology
Wuji Cailiao Xuebao/Journal of Inorganic Materials
Chinese Journal of Inorganic Chemistry
Arthritis Rheumatol
Chemical Engineering Journal
Chinese Journal of Catalysis
Dna Repair (Amst)
The Journal of Biological Chemistry
Wuli Huaxue Xuebao/ Acta Physico Chimica Sinica
Wuli Huaxue Xuebao/ Acta Physico Chimica Sinica
Acta Biochimica Et Biophysica Sinica
Journal of Materials Science
Catalysis Communications
Journal of Molecular Catalysis A: Chemical
Scientific Reports
Canadian Journal of Chemical Engineering
Journal of Medical Imaging (Bellingham, Wash.)
Nature Communications
Scientific Reports
Nucleic Acids Res
Proc Natl Acad Sci U S A
Catalysis Science and Technology
Catalysis Science and Technology
Journal of Colloid and Interface Science
Chemical Engineering Journal
Cancer Discov
Bmc Molecular Biology
Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
Catalysis Communications
Nature Communications
Dalton Transactions (Cambridge, England : 2003)
Journal of Molecular Catalysis A: Chemical
Molecular and Cellular Biology
Wuli Huaxue Xuebao/ Acta Physico Chimica Sinica
Nature Communications
Journal of Molecular Catalysis A: Chemical
Journal of Medical Imaging (Bellingham, Wash.)
Chinese Journal of Catalysis
Nucleic Acids Res
Nucleic Acids Res
J Magn Reson Imaging
Breast Cancer Res
Plos One
Journal of Xi'an Jiaotong University (Medical Sciences)
Chinese Journal of Inorganic Chemistry
Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
The Journal of Biological Chemistry
Chinese Journal of Catalysis
Chinese Journal of Catalysis
Chinese Journal of Inorganic Chemistry
Scand J Gastroenterol
Phys Med Biol
Magn Reson Med
Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics
Genes Cells
Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics
Molecular and Cellular Biology
Acad Radiol
Journal of Cell Science
Nucleic Acids Res
Journal of Xi'an Jiaotong University (Medical Sciences)
Medical Physics
Journal of Xi'an Jiaotong University (Medical Sciences)
Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
Proceedings of the National Academy of Sciences of the United States of America
Academic Radiology
The Embo Journal
Molecular and Cellular Biology
Annals of Neurology
Neuroscience Research
The Journal of Biological Chemistry
Molecular Cell
Biochemical and Biophysical Research Communications
Acta Anatomica Sinica
Acta Anatomica Sinica
Neuroscience Bulletin
Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
Journal of Cell Science
The Journal of Biological Chemistry
Academic Radiology
The Journal of Experimental Medicine
Nucleic Acids Res
The Journal of Biological Chemistry
Proceedings of the National Academy of Sciences of the United States of America
International Congress Series
Chinese Journal of Neuroscience
Medical Physics
Medical Physics
Molecular and Cellular Biology
Molecular and Cellular Biology
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
International Journal of Cardiac Imaging
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Progress in Biomedical Optics and Imaging Proceedings of Spie
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Medical Physics
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Progress in Biomedical Optics and Imaging Proceedings of Spie
Medical Physics
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Progress in Biomedical Optics and Imaging Proceedings of Spie
Medical Physics
Medical Physics
2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Progress in Biomedical Optics and Imaging Proceedings of Spie
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Medical Physics
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Offices & Contact
Durham, NC
27710 424 CARL, Box 3054
Durham, NC
27710