Marilyn Telen
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Overview
Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.
Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..
Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.
Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.
Key Words:
Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms
Positions
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D. in the School of Medicine
2001 School of Medicine
Professor of Medicine in the School of Medicine
1995 School of Medicine
Associate Professor of Pathology in the School of Medicine
1996 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1980 School of Medicine
Affiliate, Duke Global Health Institute in the Institutes and Provost's Academic Units
2018 Institutes and Provost's Academic Units
Education
M.D. 1977
1977 New York University
Intern, Medicine
1978 State University of New York - Buffalo
Resident, Medicine
1980 State University of New York - Buffalo
Fellowship, Hematology/ Oncology
1983 Duke University School of Medicine
Publications, Grants & Awards
- Grants (63)
- Awards (2)
- Academics Articles (284)
- Conference Pages (90)
- Book Sections (6)
National Institutes of Health
Global Blood Therapeutics, Inc.
National Institutes of Health
National Institutes of Health
National Institutes of Health
FORMA Therapeutics, Inc.
FORMA Therapeutics, Inc.
Global Blood Therapeutics, Inc.
National Institutes of Health
FORMA Therapeutics, Inc.
BioMedomics, Inc.
University of Maryland, Baltimore
National Institutes of Health
Food and Drug Administration
University of Pittsburgh
University of Pittsburgh
Food and Drug Administration
FORMA Therapeutics, Inc.
Doris Duke Charitable Foundation, Inc.
National Institutes of Health
University of Pittsburgh
Doris Duke Charitable Foundation
National Institutes of Health
Agency for Healthcare Research and Quality
Vanderbilt University
Cooley's Anemia Foundation
National Institutes of Health
National Institutes of Health
Pfizer, Inc.
National Institutes of Health
Doris Duke Charitable Foundation
National Institutes of Health
BioMedomics, Inc.
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Agency for Healthcare Research and Quality
National Institutes of Health
National Institutes of Health
National Heart, Lung, and Blood Institute
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Council for International Exchange of Scholars
American Association for the Advancement of Science
Clin J Am Soc Nephrol
Blood Adv
Drugs Aging
Haematologica
Hematol Oncol Clin North Am
Nature Human Behaviour
Molecules (Basel, Switzerland)
Nature Communications
J Clin Invest
Bmc Public Health
Genome Medicine
Bmc Public Health
Nature Communications
Nature Communications
Haematologica
Genome Medicine
Nature Communications
Blood Cells Mol Dis
Nature Communications
Haematologica
Nature Communications
Nat Rev Drug Discov
Am J Hematol
Am J Hematol
Nature Communications
Nature Communications
Nature Communications
Blood Advances
Isbt Science Series
Immunohematology
Br J Haematol
Plos One
Bmc Genomics
American Journal of Respiratory and Critical Care Medicine
Hematol Oncol Clin North Am
American Journal of Respiratory and Critical Care Medicine
Hematology/Oncology Clinics of North America
Transactions of the American Clinical and Climatological Association
Clinical and Translational Science
Cell Host Microbe
Isbt Science Series
Drugs of the Future
Frontiers in Optics, FIO 2012
Drugs of the Future
Plos One
Journal of the National Medical Association
American Journal of Hematology
American Journal of Hematology
Nucleic Acid Ther
Haemophilia : the Official Journal of the World Federation of Hemophilia
Journal of Biomedical Optics
Br J Haematol
American Journal of Respiratory and Critical Care Medicine
Health Outcomes Research in Medicine
The New England Journal of Medicine
Am J Hematol
Am J Hematol
Am J Hematol
Br J Haematol
Transfusion
Br J Haematol
American Journal of Hematology
Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Proceedings of the National Academy of Sciences of the United States of America
Blood
British Journal of Haematology
Oncology & Hematology Review (Us)
Hematology. American Society of Hematology. Education Program
Bone Marrow Transplantation
Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
Hematology/Oncology Clinics of North America
Journal of Thrombosis and Haemostasis : Jth
Transfusion Medicine Reviews
Archives of Dermatological Research
American Journal of Hematology
Blood
Current Hematology Reports
The Annals of Thoracic Surgery
Hematology. American Society of Hematology. Education Program
Blood
Blood
Seminars in Hematology
Transfusion
Transfusion
The Journal of Biological Chemistry
Immunohematology
Medical Oncology (Northwood, London, England)
Seminars in Hematology
Immunohematology
Transfusion
Transfusion Medicine Reviews
Faseb Journal
The Journal of Biological Chemistry
North Carolina Medical Journal
The Journal of Clinical Investigation
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Transfusion
Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
Current Opinion in Hematology
Seminars in Hematology
Transfusion
The Journal of Biological Chemistry
The New England Journal of Medicine
Transfusion
Transfusion
Hepatology (Baltimore, Md.)
Transfusion
Transfusion Medicine Reviews
Immunohematology
Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
Transfusion
Clinical Research
Current Opinion in Hematology
The Journal of Biological Chemistry
The Journal of Immunology
Clinical Research
Transfusion
Transfusion
Laboratory Investigation
Laboratory Investigation
Transfusion
Transfusion
Transfusion
Transfusion
Transfusion
Bailliere'S Clinical Haematology
Transfusion
The Journal of Clinical Investigation
The Journal of Immunology
American Journal of Hematology
Immunohematology
Clinical Research
Journal of Acquired Immune Deficiency Syndromes
Blood
The Journal of Immunology
The Journal of Experimental Medicine
Clinical Research
Revue Francaise De Transfusion Et Immuno Hematologie
Revue Francaise De Transfusion Et Immuno Hematologie
Transfusion
Vox Sanguinis
Transfusion
Human Immunology
Blood
Journal of Immunogenetics
The Journal of Clinical Investigation
The Journal of Immunology
The Journal of Immunology
The Journal of Clinical Investigation
Clinical Research
British Journal of Haematology
British Journal of Haematology
Blood
Blood
Progress in Biomedical Optics and Imaging Proceedings of Spie
Blood
Blood
Blood
Blood
American Journal of Human Genetics
American Journal of Human Genetics
Blood
ALLOIMMUNITY: 1993 AND BEYOND
Molecular Hematology
Wintrobe's Clinical Hematology ...
Wintrobe's clinical hematology
Molecular Basis of Human Blood Group Antigens
Blood Cell Biochemistry
Offices & Contact
Durham, NC
27710 Duke Box 2615
Durham, NC
27710