Mark Oldham
Mark Oldham

Mark Oldham

Professor of Radiation Oncology


Dr Oldham is the Director of the Duke Medical Physics MS/PhD Graduate Program, and Professor in the Department of Radiation Oncology, with a secondary appointment in the Physics Department at Duke. 

Main current research interests include: FLASH radiation therapy, exploring FLASH mechanisms utilizing the Duke High Intensity Gamma Source (HIGS), a nuclear research accelerator on the Duke campus.  Recent work selected for best in Physics at the annual AAPM meeting.  Radiation and Immunotherapy utilizing mini-grids. Radiation Therapy Enhanced by Cherenkov photo-Activation (RECA) and Comprehensive 3D dosimetry.

Dr Oldham has patented and published on several novel radiation treatment techniques (including XPACT and RECA - Radiotherapy Enhanced by Cherenkov photo-Activation) with exiting potential to invoke systemic anti-cancer immunogenic response.  A phase I clinical trial of XPACT is underway.  The lab has pioneered novel pre-clinical treatment capabilities including mini-beam grids, and ultra-high-resolution IMRT.  The lab has also developed novel optical imaging techniques for high-resolution 3D imaging of vascular networks and fluorescent gene expression in un-sectioned tissue samples.


Professor of Radiation Oncology in the School of Medicine

2021 School of Medicine

Professor of Physics in the Trinity College of Arts & Sciences

2024 Trinity College of Arts & Sciences

Member of the Duke Cancer Institute in the School of Medicine

2016 School of Medicine


Ph.D. 1991

1991 Newcastle University (United Kingdom)

Publications, Grants & Awards

Offices & Contact

04214 Duke South Clinics
Durham, NC
Box 3295 Med Ctr
Durham, NC