
Mark Oldham
Professor of Radiation OncologyOverview
Dr Oldham is the Director of the Duke Medical Physics MS/PhD Graduate Program, and Professor in the Department of Radiation Oncology, with a secondary appointment in the Physics Department at Duke.
Main current research interests include: FLASH radiation therapy, exploring FLASH mechanisms utilizing the Duke High Intensity Gamma Source (HIGS), a nuclear research accelerator on the Duke campus. Recent work selected for best in Physics at the annual AAPM meeting. Radiation and Immunotherapy utilizing mini-grids. Radiation Therapy Enhanced by Cherenkov photo-Activation (RECA) and Comprehensive 3D dosimetry.
Dr Oldham has patented and published on several novel radiation treatment techniques (including XPACT and RECA - Radiotherapy Enhanced by Cherenkov photo-Activation) with exiting potential to invoke systemic anti-cancer immunogenic response. A phase I clinical trial of XPACT is underway. The lab has pioneered novel pre-clinical treatment capabilities including mini-beam grids, and ultra-high-resolution IMRT. The lab has also developed novel optical imaging techniques for high-resolution 3D imaging of vascular networks and fluorescent gene expression in un-sectioned tissue samples.
Positions
Professor of Radiation Oncology in the School of Medicine
2021 School of Medicine
Professor of Physics in the Trinity College of Arts & Sciences
2024 Trinity College of Arts & Sciences
Member of the Duke Cancer Institute in the School of Medicine
2016 School of Medicine
Education
Ph.D. 1991
1991 Newcastle University (United Kingdom)
Publications, Grants & Awards
Offices & Contact
Durham, NC
27710
Durham, NC