Mary Helen Foster
Professor of MedicineOverview
Research in the Foster Lab focuses on autoimmune glomerulonephritis, a major cause of acute and chronic kidney disease worldwide.
Our experiments explore the origins and regulation of the pathogenic immune responses that underlie glomerulonephritis, and are designed to: identify tolerance mechanisms that regulate nephritogenic lymphocytes, with an emphasis on B cells and autoantibodies; determine the molecular basis of tolerance; identify defects in immune regulation and the contributions of genetic autoimmune predisposition; and identify environmental disease triggers. These experiments use novel models relevant to immune nephritis in both kidney-restricted and systemic autoimmunity (Goodpasture syndrome and systemic lupus erythematosus, respectively), that are amenable to mechanistic dissection using basic immunological, molecular biological, and proteomics approaches. An ultimate goal is to advance novel diagnostic and therapeutic approaches to improve the lives of patients.
Positions
Professor of Medicine in the School of Medicine
2019 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2000 School of Medicine
Education
M.D. 1982
1982 University of North Carolina, Chapel Hill
Medical Resident, Medicine
1985 University of Virginia
Fellow in Nephrology, Medicine
1989 Tufts University
Publications, Grants & Awards
Offices & Contact
Durham, NC
27710 Duke Box 103015
Durham, NC
27710