Mary Markert
Professor Emeritus of Pediatrics
Overview
Dr. Markert is currently investigating cultured thymus tissue implantatoin in children with congenital athymia. Congenital athymia is a fatal disease as the patients have no T cells to defend against infection. There are several etiologies of congenital athymia including 22q11.2 deletion syndrome, CHARGE (coloboma, heart defects, choanal atresia, growth or mental retardation, genital abnormalities and ear anomalies and or deafness. Complete DiGeorge anomaly is a designation that encompasses the above in addition with patients with athymia who have heart and/or parathyroid defects. In research studies, patients with athymia who have no T cells are given postnatal cultured thymus tissue implants (CTTI). Of 95 patients with congenital athymia approximately 72% have developed T cells and survive. Dr. Markert is now studying patients previously given CTTI to learn how long the tissue functions and why the T cell numbers in her post thymus transplantation patients remain low for age - similar to the T cell numbers in patients with partial DiGeorge anomaly who do not need CTTI. In 2012, Dr. Markert began studies in an animal model to use CTTI to induce tolerance to solid organ transplants. This work in rats has been published and showed tolerance induction for solid organ transplants.
Positions
Professor Emeritus of Pediatrics in the School of Medicine
2021 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1982 School of Medicine
Education
Ph.D. 1981
1981 Duke University
M.D. 1982
1982 Duke University
Publications, Grants & Awards
- Grants (35)
- Academics Articles (108)
- Conference Pages (30)
- Book Sections (5)
National Institutes of Health
Enzyvant
Orphavant Sciences GmbH
National Institutes of Health
Enzyvant Sciences Ltd.
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Food and Drug Administration
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
J Clin Invest
The Journal of Thoracic and Cardiovascular Surgery
Frontiers in Immunology
J Clin Invest
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
Blood Adv
Jci Insight
Hum Mol Genet
The Journal of Allergy and Clinical Immunology
Annals of Allergy, Asthma & Immunology
Journal of Visualized Experiments : Jove
Pediatric Critical Care Medicine
The Journal of Allergy and Clinical Immunology
Bmc Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
J Clin Immunol
The Journal of Allergy and Clinical Immunology
Respiratory Care
The Journal of Allergy and Clinical Immunology
Blood
The Journal of Allergy and Clinical Immunology
Clin Immunol
The Journal of Allergy and Clinical Immunology
Plos Computational Biology
Immunologic Research
Immunologic Research
Clinical and Experimental Immunology
The Journal of Immunology
The Journal of Allergy and Clinical Immunology
J Cutan Pathol
Clinical Immunology (Orlando, Fla.)
Seminars in Immunology
Clinical Immunology (Orlando, Fla.)
Bioinformatics (Oxford, England)
Bioinformatics (Oxford, England)
J Pediatr Surg
Journal of Allergy and Clinical Immunology
The Journal of Immunology
Human Gene Therapy
Clinical Immunology (Orlando, Fla.)
Clinical Immunology (Orlando, Fla.)
Clinical Immunology (Orlando, Fla.)
Aids Research and Human Retroviruses
Human Gene Therapy
Human Gene Therapy
Aids Research and Human Retroviruses
Annual Review of Immunology
The New England Journal of Medicine
Clinical Immunology (Orlando, Fla.)
The New England Journal of Medicine
Human Gene Therapy
Human Gene Therapy
The Journal of Pediatrics
Pediatric Pulmonology
The Journal of Pediatrics
Journal of Clinical Immunology
The Journal of Immunology
Journal of Allergy and Clinical Immunology
Clinical Immunology and Immunopathology
Human Mutation
Faseb Journal
Aids Research and Human Retroviruses
Aids Research and Human Retroviruses
Faseb Journal
Pediatric Research
Science (New York, N.Y.)
American Journal of Human Genetics
The Journal of Immunology
Faseb Journal
Immunodeficiency
Seminars in Hematology
Human Molecular Genetics
Human Molecular Genetics
Seminars in Hematology
American Journal of Human Genetics
The Journal of Biological Chemistry
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Immunodeficiency Reviews
American Journal of Human Genetics
The Journal of Clinical Investigation
Journal of Clinical Immunology
The Journal of Immunology
The New England Journal of Medicine
The New England Journal of Medicine
The Journal of Immunology
Pediatric Research
The Journal of Immunology
The Journal of Immunology
Proceedings of the National Academy of Sciences of the United States of America
Pediatric Transplantation
Journal of Allergy and Clinical Immunology
Journal of Clinical Immunology
The Journal of Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
The Journal of Immunology
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Clinical Immunology
Intensive Care Medicine
PROCEEDINGS OF THE 15TH MEETING OF THE EUROPEAN SOCIETY IMMUNODEFICIENCIES (ESID)
Journal of Allergy and Clinical Immunology
The Journal of Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Immunology (Orlando, Fla.)
Journal of Allergy and Clinical Immunology
Clinical Immunology (Orlando, Fla.)
Clinical Immunology (Orlando, Fla.)
Pediatric Research
Clinical Research
Journal of Allergy and Clinical Immunology
Federation Proceedings
Stiehm's Immune Deficiencies: Inborn Errors of Immunity
Stiehm's Immune Deficiencies: Inborn Errors of Immunity
Stiehm's Immune Deficiencies
Clinical Immunology: Principles and Practice: Fourth Edition
Clinical Immunology: Principles and Practice Expert Consult: Online and Print
Offices & Contact
Durham, NC
27710 Rm 101 Research Park 4, Research Dr.
Durham, NC
27710