Michael Kastan
William and Jane Shingleton Distinguished Professor of Pharmacology and Cancer BiologyOverview
Dr. Kastan earned his M.D./Ph.D. from Washington University School of Medicine and did his clinical training in Pediatrics and Pediatric Hematology-Oncology at Johns Hopkins. He was a Professor of Oncology at Johns Hopkins prior to becoming Chair of the Hematology-Oncology Department and later Cancer Center Director at St. Jude Children’s Research Hospital, before moving to Duke in 2011, where he currently serves as the Executive Director of the Duke Cancer Institute and is the William and Jane Shingleton Professor of Pharmacology and Cancer Biology. His laboratory research has focused on cellular responses to DNA damage, including many highly cited publications reporting the roles of p53 and ATM in DNA damage signaling. Among his numerous honors are election to the National Academy of Sciences, National Academy of Medicine, and the American Academy of Arts and Sciences, and receipt of the AACR-G.H.A. Clowes Memorial Award and Failla Award from the Radiation Research Society. He has served as Chair of the Board of Scientific Counselors of the National Cancer Institute (NCI), on the Boards of Directors of the American Association for Cancer Research (AACR) and the American Association of Cancer Institutes (AACI), and as Editor-in-Chief of the journal Molecular Cancer Research. His lab continues to study molecular and biochemical controls of cellular stress responses, particularly those related to DNA damage, and has spun out two companies focused on novel anti-cancer therapeutics.
Positions
William and Jane Shingleton Distinguished Professor of Pharmacology and Cancer Biology in the School of Medicine
2012 School of Medicine
Professor of Pharmacology and Cancer Biology in the School of Medicine
2012 School of Medicine
Director of the Duke Cancer Institute in the School of Medicine
2011 School of Medicine
Professor of Pediatrics in the School of Medicine
2012 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2010 School of Medicine
Education
M.D. 1984
1984 Washington University in St. Louis
Ph.D. 1984
1984 Washington University in St. Louis
Publications, Grants & Awards
- Grants (29)
- Awards (11)
- Academics Articles (212)
- Book Sections (3)
- Conference Pages (11)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Gray Foundation
V Foundation for Cancer Research
National Institutes of Health
XRAD THERAPEUTICS, INC.
National Institutes of Health
National Institutes of Health
V Foundation for Cancer Research
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institute of Environmental Health Sciences
National Institutes of Health
National Institutes of Health
University of Pennsylvania
National Institutes of Health
National Institutes of Health
The Farrah Fawcett Foundation
A-T Children's Project
National Institutes of Health
National Cancer Institute
GlaxoSmithKline
Radiation Research Society
American Association for Cancer Research
National Academy of Sciences
American Academy of Arts and Sciences
American Association for the Advancement of Science
National Academy of Medicine
American Association for Cancer Research
National Institutes of Health
Association of American Physicians
Thomson Reuters
American Society of Clinical Investigation
Radiat Res
Journal of Pediatric Hematology/Oncology
Diabetol Metab Syndr
Oncoscience
Cancer Discov
Cell Res
Sci Transl Med
Journal of Medicinal Chemistry
Annu Rev Med
Cancer Research
The Embo Journal
J Biomol Screen
Pediatr Blood Cancer
Proc Natl Acad Sci U S A
Nat Cell Biol
Nat Rev Drug Discov
Nature Cell Biology
Mol Cancer Res
Int J Radiat Oncol Biol Phys
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
International Journal of Radiation Oncology, Biology, Physics
Cancer Research
Cancer Epidemiol
Cancer Research
Proc Natl Acad Sci U S A
Mol Cell
J Virol
Geburtshilfe Und Frauenheilkunde
The Journal of Clinical Investigation
Molecular and Cellular Biology
Molecular Cancer Research : Mcr
The Journal of Clinical Investigation
Molecular Cancer Research : Mcr
Molecular Cancer Research : Mcr
Nature Cell Biology
Nature Cell Biology
Molecular Cancer Research : Mcr
Blood Cells, Molecules, and Diseases
Cell Metabolism
Cancer Genetics and Cytogenetics
The Journal of Cell Biology
Genes & Development
Scientist
Cell
Cold Spring Harbor Symposia on Quantitative Biology
Molecular and Cellular Biology
Molecular and Cellular Biology
Plos Biology
Trends in Cell Biology
Genes & Development
Genes & Development
Cancer Research
Molecular Cancer Research : Mcr
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
Methods in Molecular Biology (Clifton, N.J.)
Molecular Cancer Research : Mcr
Gene Therapy
Molecular Cancer Research : Mcr
Nature Cell Biology
Molecular Cancer Research : Mcr
Cancer Research
Genes & Development
Molecular and Cellular Biology
Molecular Biology of the Cell
Acta Neuropathologica
Genes & Development
Molecular and Cellular Biology
Molecular and Cellular Biology
Acta Oncologica (Stockholm, Sweden)
Advances in Cancer Research
Nature Reviews. Molecular Cell Biology
Nature Cell Biology
Cold Spring Harbor Symposia on Quantitative Biology
Methods in Molecular Biology (Clifton, N.J.)
The Journal of Biological Chemistry
Biochimica Et Biophysica Acta
The Journal of Biological Chemistry
In Vivo (Athens, Greece)
Cancer Research
Genes & Development
Bone Marrow Transplantation
Genes & Development
Science (New York, N.Y.)
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Proceedings of the National Academy of Sciences of the United States of America
Oncogene
Proceedings of the National Academy of Sciences of the United States of America
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Genes & Development
Science (New York, N.Y.)
Faseb Journal
Nature Medicine
Cancer Research
Nature Genetics
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Research
Faseb Journal
Journal of Clinical Pathology
Molecular and Cellular Biology
Current Topics in Microbiology and Immunology
Advances in Cancer Research
Cancer Surveys
Advances in Pharmacology (San Diego, Calif.)
Cancer Research
The American Journal of Pathology
The New England Journal of Medicine
International Journal of Oncology
Genes & Development
Cancer Metastasis Reviews
Seminars in Cancer Biology
Important Advances in Oncology
The Journal of Biological Chemistry
Science (New York, N.Y.)
Science (New York, N.Y.)
Proceedings of the National Academy of Sciences of the United States of America
Cancer Research
Proceedings of the National Academy of Sciences of the United States of America
Cancer Research
Molecular and Cellular Biology
Journal of Cellular Biochemistry
Journal of Cellular Biochemistry
Pediatric Hematology and Oncology
Cold Spring Harbor Symposia on Quantitative Biology
Advances in Experimental Medicine and Biology
Environmental Health Perspectives
Nature Genetics
Cancer Research
Proceedings of the National Academy of Sciences of the United States of America
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research
Journal of Cellular Biochemistry
Advances in Experimental Medicine and Biology
Proceedings of the National Academy of Sciences of the United States of America
Journal of Immunological Methods
Bone Marrow Transplantation
Blood
Current Opinion in Oncology
The American Journal of Pediatric Hematology/Oncology
The American Journal of Pediatric Hematology/Oncology
Experimental Hematology
Biochemistry
Federation Proceedings
Proceedings of the American Association for Cancer Research
Abeloff’s Clinical Oncology
Abeloff's Clinical Oncology: Fifth Edition
25 Years of p53 Research
Molecular Cancer Research : Mcr
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Abstracts of Papers of the American Chemical Society
Neuro Oncology
Breast Cancer Res
Breast Cancer Research and Treatment
Arteriosclerosis, Thrombosis, and Vascular Biology
American Journal of Human Genetics
RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 DUMC Box 3917, 10 Bryan Searle Drive, Rm 422
Durham, NC
27710