Michael Morse
Professor of MedicineOverview
We are studying the use of immune therapies to treat various cancers, including gastrointestinal, breast, and lung cancers and melanoma. These therapies include vaccines based on dendritic cells developed in our laboratory as well as vaccines based on peptides, viral vectors, and DNA plasmids. Our group is also a national leader in the development and use of laboratory assays for demonstrating immunologic responses to cancer vaccines. Finally, we are developing immunotherapies based on adoptive transfer of tumor and viral antigen-specific T cells.
Our current clinical trials include phase I and II studies of immunotherapy for: patients with metastatic malignancies expressing CEA, pancreatic cancer, colorectal cancer, breast cancer, and ovarian cancer, and leukemias following HSCT. My clinical area of expertise is in gastrointestinal oncology, in particular, the treatment of hepatic malignancies, and malignant melanoma.
Key words: dendritic cells, immunotherapy, vaccines, T cells, gastrointestinal oncology, melanoma, hepatoma
Positions
Professor of Medicine in the School of Medicine
2012 School of Medicine
Professor in the Department of Surgery in the School of Medicine
2015 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1993 School of Medicine
Education
M.D. 1990
1990 Yale University
Medical Resident, Medicine
1993 University of Washington
Fellow in Hematology-Oncology, Medicine
1996 Duke University
Clinical Trials
Publications, Grants & Awards
- Grants (43)
- Academics Articles (392)
- Conference Pages (53)
- Book Sections (11)
National Institutes of Health
Department of Defense
Department of Defense
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Department of Defense
Department of Defense
National Institutes of Health
Department of Defense
Ipsen Biopharmaceuticals, Inc.
AlphaVax, Inc.
Chugai Pharmaceutical Company, Ltd.
PsiOxus Therapeutics Ltd.
Department of Defense
Onyx Pharmaceuticals, Inc
Department of Defense
Lexicon Pharmaceuticals
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Cancer Institute
Agency for Healthcare Research and Quality
National Institutes of Health
National Institutes of Health
Cancer Medicine
Annals of Surgical Oncology
Cancer Gene Ther
Ca: a Cancer Journal for Clinicians
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Mol Cancer Ther
Journal for Immunotherapy of Cancer
Int J Radiat Oncol Biol Phys
Target Oncol
American Journal of Cancer Research
Human Pathology: Case Reports
Journal for Immunotherapy of Cancer
Clinical Cancer Research
Eur J Nucl Med Mol Imaging
Clinical Cancer Research
Expert Opin Biol Ther
Communications Biology
Oncologist
American Journal of Translational Research
Cancer Management and Research
Cancer Management and Research
American Journal of Cancer Research
Int J Hyperthermia
Clin Breast Cancer
Cancer Chemother Pharmacol
Clinical Cancer Research
Br J Dermatol
Immunotherapy
Journal of Gastrointestinal Oncology
Journal of Clinical Oncology
Clinical Cancer Research
Journal of Thrombosis and Thrombolysis
Molecular Therapy Oncolytics
Journal for Immunotherapy of Cancer
Clinical Cancer Research
The Biochemical Journal
Clinical Cancer Research
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Am Soc Clin Oncol Educ Book
Journal of Clinical Oncology
Cancer Chemother Pharmacol
Frontiers in Oncology
Journal for Immunotherapy of Cancer
Clinical Cancer Research
Cancer Immunol Res
Clinical Cancer Research
Cancer Chemother Pharmacol
Oncoimmunology
Clinical Colorectal Cancer
Cancer Immunol Immunother
Journal of Gastrointestinal Oncology
Cancer Chemother Pharmacol
Current Treatment Options in Oncology
Current Colorectal Cancer Reports
Thorac Surg Clin
Cell Death & Disease
European Heart Journal
Cancer Immunology Research
Journal for Immunotherapy of Cancer
Breast Cancer Res
Asia Pacific Journal of Clinical Oncology
Cancer Immunol Immunother
Oncoimmunology
Cancer Immunol Immunother
Journal of Clinical Oncology
Breast Cancer Res
Cancer Medicine
Drug Design, Development and Therapy
Invest New Drugs
Annals of Surgical Oncology
Annals of Surgical Oncology
Journal of Personalized Medicine
Journal for Immunotherapy of Cancer
Immunotherapy
Current Colorectal Cancer Reports
Molecular Cancer Therapeutics
J Cancer Res Clin Oncol
J Clin Invest
Agricultural Sustainability
Cancer Immunol Immunother
Cancer Immunol Immunother
Breast Cancer Res Treat
Journal of Translational Medicine
Am Soc Clin Oncol Educ Book
Current Colorectal Cancer Reports
Cancer Immunol Immunother
The New England Journal of Medicine
Clinical Colorectal Cancer
Journal of Translational Medicine
Cancer Chemother Pharmacol
Cancer Chemother Pharmacol
Mol Cancer Ther
Expert Opin Investig Drugs
Breast Cancer Res
Pacing Clin Electrophysiol
Eur J Immunol
Int J Radiat Oncol Biol Phys
Eur J Immunol
Clinical Colorectal Cancer
Clinical Cancer Research
J Oncol Pharm Pract
Expert Rev Vaccines
Clinical Cancer Research
Gastrointestinal Cancer Research
Cancer Chemother Pharmacol
Cancer Chemother Pharmacol
Anticancer Res
Methods Mol Biol
Curr Opin Investig Drugs
Cancer Invest
Expert Opin Biol Ther
Case Reports in Oncology
Anticancer Res
Clinical Cancer Research
Curr Opin Mol Ther
Journal of Supportive Oncology
Anticancer Res
Gastrointestinal Cancer Research
Curr Pharm Biotechnol
Cancer Gene Ther
Curr Mol Med
Journal of Translational Medicine
Annals of Surgical Oncology
Ann Oncol
Journal of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Expert Opin Biol Ther
Curr Opin Mol Ther
Int J Radiat Oncol Biol Phys
J Gastrointest Surg
The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (Aimn) [And] the International Association of Radiopharmacology (Iar), [And] Section of the Society Of..
Clinical Advances in Hematology & Oncology : H&O
Current Colorectal Cancer Reports
Journal of Clinical Oncology
Oncology (Williston Park, N.Y.)
Cancer Immunology, Immunotherapy
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bmc Immunology
The New England Journal of Medicine
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Molecular Cancer Therapeutics
Clinical Trials
International Journal of Radiation Oncology, Biology, Physics
Annals of Surgical Oncology
Journal of Evaluation in Clinical Practice
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology
Surgical Oncology Clinics of North America
Minerva Biotecnologica
Expert Opin Biol Ther
Expert Opin Biol Ther
Jnccn Journal of the National Comprehensive Cancer Network
Journal of Translational Medicine
Jnccn Journal of the National Comprehensive Cancer Network
International Journal of Radiation Oncology, Biology, Physics
Frontiers in Bioscience : a Journal and Virtual Library
Expert Opin Biol Ther
International Journal of Radiation Oncology, Biology, Physics
Journal of the American College of Surgeons
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Expert Opinion on Biological Therapy
Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment
Journal of Translational Medicine
Enhancer Biotherapy of Cancer
Expert Opin Biol Ther
Journal of Cellular Biochemistry
Cancer Immunology, Immunotherapy
Journal of Clinical Oncology
Materials Research Society Symposium Proceedings
Aip Conference Proceedings
Evidence Report/Technology Assessment
Supportive Cancer Therapy
Journal of Clinical Oncology
Current Opinion in Molecular Therapeutics
Expert Rev Vaccines
Current Opinion in Molecular Therapeutics
Cancer Investigation
Clinical Colorectal Cancer
Physica Status Solidi C: Current Topics in Solid State Physics
Applied Surface Science
International Reviews of Immunology
Journal of Vacuum Science & Technology. B, Microelectronics and Nanometer Structures : Processing, Measurement, and Phenomena : an Official Journal of the American Vacuum Society
Idrugs : the Investigational Drugs Journal
The Journal of Thoracic and Cardiovascular Surgery
Expert Opin Biol Ther
Idrugs : the Investigational Drugs Journal
Expert Opin Pharmacother
Current Opinion in Molecular Therapeutics
The New England Journal of Medicine
The New England Journal of Medicine
Biochemical and Biophysical Research Communications
International Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clin Colon Rectal Surg
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology
Journal of Clinical Oncology
The Annals of Pharmacotherapy
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Current Opinion in Molecular Therapeutics
Annals of Surgical Oncology
Journal of Translational Medicine
Current Opinion in Molecular Therapeutics
Nature Clinical Practice. Oncology
Diseases of the Colon & Rectum
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Crystal Research and Technology
Cancer Treatment and Research
Journal of Applied Research
Journal of Applied Research
Journal of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
International Journal of Radiation Oncology, Biology, Physics
Current Problems in Surgery
Gastrointestinal Endoscopy
Molecular Biotechnology
Control Clin Trials
Annals of Surgery
Cancer Investigation
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Journal of Surgical Oncology
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Clinical Breast Cancer
Current Opinion in Molecular Therapeutics
Cancer Chemotherapy and Biological Response Modifiers
Journal of Neuro Oncology
International Reviews of Immunology
American Journal of Cancer
Seminars in Colon and Rectal Surgery
Expert Opinion on Biological Therapy
Expert Opin Emerg Drugs
Journal of Leukocyte Biology
Journal of Hematotherapy & Stem Cell Research
World Journal of Surgery
Current Opinion in Molecular Therapeutics
Expert Opinion on Biological Therapy
Annals of Surgery
Expert Opinion on Biological Therapy
Current Opinion in Molecular Therapeutics
Expert Opinion on Biological Therapy
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Cancer Chemotherapy and Biological Response Modifiers
International Journal of Gastrointestinal Cancer
Current Opinion in Molecular Therapeutics
Annals of Surgical Oncology
Annals of Surgical Oncology
Current Opinion in Molecular Therapeutics
Idrugs : the Investigational Drugs Journal
Idrugs : the Investigational Drugs Journal
Journal of Virology
Journal of the National Cancer Institute
Annals of Surgery
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Annals of Surgical Oncology
Expert Opinion on Biological Therapy
Cancer Research
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Anticancer Research
Critical Reviews in Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of the National Cancer Institute
Current Opinion in Molecular Therapeutics
Current Opinion in Molecular Therapeutics
Idrugs : the Investigational Drugs Journal
Current Opinion in Molecular Therapeutics
Idrugs : the Investigational Drugs Journal
Current Opinion in Molecular Therapeutics
Clinical Lung Cancer
Current Opinion in Oncologic, Endocrine and Metabolic Investigational Drugs
Advances in Experimental Medicine and Biology
Journal of Hematotherapy & Stem Cell Research
Curr Opin Mol Ther
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Hepatology (Baltimore, Md.)
Clinical Lung Cancer
International Journal of Cancer
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Annals of Surgical Oncology
Cancer Research
Expert Opin Investig Drugs
Cancer Research
The Journal of Immunology
Nature Biotechnology
Cytokines, Cellular & Molecular Therapy
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Blood
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Cancer Gene Therapy
Journal of Applied Physiology (Bethesda, Md. : 1985)
American Journal of Surgical Pathology
Cancer Research
The Journal of Clinical Endocrinology and Metabolism
Molecular Therapy
Journal for Immunotherapy of Cancer
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bju International
Annals of Oncology
European Journal of Cancer
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Research
Cancer Research
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
International Journal of Radiation Oncology, Biology, Physics
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Surgical Oncology
Faseb Journal
Annals of Surgical Oncology
Current Cancer Research
MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS
Malignant Liver Tumors: Current and Emerging Therapies: Third Edition
Malignant Liver Tumors: Current and Emerging Therapies: Third Edition
Malignant Liver Tumors: Current and Emerging Therapies: Third Edition
Genomic and Personalized Medicine, Two-Vol Set
Genomic and Personalized Medicine: V1-2
General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology
Measuring Immunity: Basic Biology and Clinical Assessment
Measuring Immunity: Basic Science and Clinical Practice
Clark H. Pinnock: Journey Toward Renewal
DCI Centers, Cancer Types & Labs
Offices & Contact
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Durham, NC
27710