Nelson Chao
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Overview
My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.
For more information see http://ed-media.mc.duke.edu/BMT.nsf
Positions
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor in the School of Medicine
2002 School of Medicine
Professor of Medicine in the School of Medicine
2001 School of Medicine
Professor in Immunology in the School of Medicine
2001 School of Medicine
Professor in Pathology in the School of Medicine
2011 School of Medicine
Chief, Division of Cell Therapy in the Department of Medicine in the School of Medicine
2004 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1996 School of Medicine
Affiliate of the Duke Regeneration Center in the School of Medicine
2021 School of Medicine
Education
M.D. 1981
1981 Yale University
Medical Resident, Medicine
1984 Stanford University
Fellow in Oncology, Medicine
1987 Stanford University
Publications, Grants & Awards
- Grants (61)
- Academics Articles (384)
- Conference Pages (11)
- Book Sections (5)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Defense Advanced Research Projects Agency
National Institutes of Health
Columbia University
National Institutes of Health
National Institutes of Health
American Society of Hematology
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Society of Hematology
National Institutes of Health
American Society of Hematology
Columbia University
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Columbia University
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Transplant Cell Ther
Jco Glob Oncol
Transplant Cell Ther
Clinical Cancer Research
Bone Marrow Transplant
Transpl Infect Dis
Transplant Cell Ther
Transplant Cell Ther
Open Forum Infectious Diseases
Frontiers in Immunology
Plos One
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Bone Marrow Transplant
Bone Marrow Transplant
Bone Marrow Transplant
Transplant Cell Ther
Clin J Oncol Nurs
Transplant Cell Ther
Blood Cancer Journal
Transplant Cell Ther
Transplant Cell Ther
Bone Marrow Transplant
Frontiers in Immunology
Global Health, Science and Practice
Biol Blood Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Science
Blood
Br J Haematol
Cancer Epidemiol
Am J Hematol
The New England Journal of Medicine
Advanced Science (Weinheim, Baden Wurttemberg, Germany)
The New England Journal of Medicine
Int J Radiat Biol
Int J Radiat Biol
Best Pract Res Clin Haematol
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Br J Dermatol
Transpl Infect Dis
Stem Cell Reports
Jama Dermatol
Nature Communications
Int J Radiat Oncol Biol Phys
Cancer Lett
Frontiers in Immunology
Int J Nanomedicine
Current Stem Cell Reports
Journal of Global Oncology
Biol Blood Marrow Transplant
Blood Cancer Journal
Bone Marrow Transplant
The New England Journal of Medicine
Open Forum Infectious Diseases
Biol Blood Marrow Transplant
Jmir Mhealth and Uhealth
Journal of Hematology & Oncology
Expert Rev Clin Pharmacol
Bone Marrow Transplant
Hematol Oncol Stem Cell Ther
Journal of Global Oncology
Stem Cell Research & Therapy
Cell Death & Disease
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Bone Marrow Transplant
Current Stem Cell Research & Therapy
Cell Reports
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Journal of Hematology & Oncology
Pediatr Blood Cancer
Int J Radiat Oncol Biol Phys
Biol Blood Marrow Transplant
Int J Radiat Oncol Biol Phys
Int J Radiat Biol
Biol Blood Marrow Transplant
J Clin Invest
Biol Blood Marrow Transplant
J Clin Invest
Radiat Res
Expert Opin Investig Drugs
Biol Blood Marrow Transplant
Frontiers in Oncology
J Leukoc Biol
Bone Marrow Transplantation
Bone Marrow Transplant
Best Pract Res Clin Haematol
Biol Blood Marrow Transplant
Bone Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Int J Radiat Oncol Biol Phys
Stem Cells Translational Medicine
Cell Reports
Biosecur Bioterror
Biol Blood Marrow Transplant
Cell Reports
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Bone Marrow Transplant
Bone Marrow Transplant
Biol Blood Marrow Transplant
Adv Hematol
Int J Radiat Oncol Biol Phys
Disaster Med Public Health Prep
Disaster Med Public Health Prep
Int J Radiat Biol
Int J Radiat Biol
Biol Blood Marrow Transplant
Bone Marrow Transplant
Biol Blood Marrow Transplant
Int J Radiat Oncol Biol Phys
Disaster Med Public Health Prep
Expert Review of Hematology
Cellular Therapy and Transplantation
Biol Blood Marrow Transplant
Current Oncology Reports
Biol Blood Marrow Transplant
Cancer Invest
Best Pract Res Clin Haematol
Stem Cells
F1000 Medicine Reports
Bone Marrow Transplant
Biol Blood Marrow Transplant
Cancer
Biol Blood Marrow Transplant
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Expert Review of Hematology
Molecular Endocrinology (Baltimore, Md.)
Bone Marrow Transplant
Curr Opin Hematol
Bone Marrow Transplantation
Biol Blood Marrow Transplant
Best Practice & Research. Clinical Haematology
Bone Marrow Transplantation
Biol Blood Marrow Transplant
Hematology. American Society of Hematology. Education Program
Blood Cells, Molecules, and Diseases
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Current Opinion in Hematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Experimental Hematology
Journal of Clinical Oncology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation
Current Opinion in Hematology
Arch Pathol Lab Med
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Proceedings of the National Academy of Sciences of the United States of America
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Stem Cells (Dayton, Ohio)
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Transplant Infectious Disease : an Official Journal of the Transplantation Society
Seminars in Hematology
The Journal of Clinical Investigation
Antimicrobial Agents and Chemotherapy
American Journal of Hematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Current Opinion in Hematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Chest
The American Journal of Surgical Pathology
Leukemia Research
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Hematology. American Society of Hematology. Education Program
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Leukemia & Lymphoma
Experimental Hematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Hematology. American Society of Hematology. Education Program
Journal of Hematotherapy & Stem Cell Research
Leukemia & Lymphoma
Drugs of the Future
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Experimental Hematology
Experimental Hematology
Molecular Therapy
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Transplantation
Bone Marrow Transplantation
Journal of Vascular and Interventional Radiology : Jvir
Journal of Hematotherapy & Stem Cell Research
American Journal of Respiratory and Critical Care Medicine
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Stem Cells (Dayton, Ohio)
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
The American Journal of Surgical Pathology
Current Opinion in Oncology
Immunology Letters
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Research Therapy and Control
Leukemia & Lymphoma
Proceedings of the National Academy of Sciences of the United States of America
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
The New England Journal of Medicine
Proceedings of the National Academy of Sciences of the United States of America
Cancer Chemotherapy and Pharmacology
Annals of the New York Academy of Sciences
The Canadian Journal of Oncology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The Journal of Immunology
Experimental Hematology
Cancer
Bone Marrow Transplantation
Experimental Hematology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
The New England Journal of Medicine
Transplantation
Transplantation
Cancer Chemotherapy and Pharmacology
Current Opinion in Immunology
Experimental Hematology
Lancet (London, England)
British Journal of Haematology
Annals of Internal Medicine
Transfusion
Progress in Clinical and Biological Research
Progress in Clinical and Biological Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Internal Medicine
New England Journal of Medicine
Experimental Hematology
Blood
Annals of Internal Medicine
Experimental Hematology
The Western Journal of Medicine
Haematology and Blood Transfusion
Clinical Transplants
Journal of Immunological Methods
The Western Journal of Medicine
Immunogenetics
Science (New York, N.Y.)
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplant
Jnccn Journal of the National Comprehensive Cancer Network
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Pediatric Blood & Cancer
Biol Blood Marrow Transplant
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Advances in Radiation Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Thomas' Hematopoietic Cell Transplantation: Fifth Edition
Thomas' Hematopoietic Cell Transplantation: Fifth Edition
Novel Developments in Stem Cell Mobilization Focus on CXCR4
Bone Marrow Transplantation Across Major Genetic Barriers
Hematopoietic Stem Cell Transplantation A Handbook for Clinicians
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 DUMC Box 3961
Durham, NC
27710