Pei Zhou
Pei Zhou

Pei Zhou

Professor of Biochemistry


The Zhou lab focuses on the elucidation of the structure and dynamics of protein–protein and protein–ligand interactions and their functions in various cellular processes. Our current efforts are directed at enzymes and protein complexes involved in bacterial membrane biosynthesis, translesion DNA synthesis, co-transcriptional regulation, and host-pathogen interactions. Our investigations of these important cellular machineries have led to the development of novel antibiotics and cancer therapeutics, as well as the establishment of new biotechnology adventures.


The Zhou lab integrates a variety of biochemical and biophysical tools, including NMR, X-ray crystallography, cryo-EM, and enzymology. The lab has played a major role in the development and application of innovative NMR technologies, including high-resolution, high-dimensional spectral reconstruction techniques.


Professor of Biochemistry in the School of Medicine

2015 School of Medicine

Professor of Chemistry in the Trinity College of Arts & Sciences

2015 Trinity College of Arts & Sciences

Member of the Duke Cancer Institute in the School of Medicine

2001 School of Medicine


Ph.D. 1998

1998 Harvard University

Post-Doct Fellow, Biological Chemistry

2001 Harvard University

Publications, Grants & Awards

Offices & Contact

270 Sands Building
Durham, NC
Duke Box 3711
Durham, NC