Pei Zhou
Professor of Biochemistry
Overview
Protein-protein interactions play a pivotal role in the regulation of various cellular processes. The formation of higher order protein complexes is frequently accompanied by extensive structural remodeling of the individual components, varying from domain re-orientation to induced folding of unstructured elements. Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for macromolecular structure determination in solution. It has the unique advantage of being capable of elucidating the dynamic behavior of proteins during the process of recognition. Recent advances in NMR techniques have enabled the study of significantly larger proteins and protein complexes. These innovations have also led to faster and more accurate structure determination. My research interests focus on the exploration of molecular recognition and conformation variability of protein complexes in crucial biomedical processes using state-of-the-art NMR techniques.
Positions
Professor of Biochemistry in the School of Medicine
2015 School of Medicine
Professor of Chemistry in the Trinity College of Arts & Sciences
2015 Trinity College of Arts & Sciences
Member of the Duke Cancer Institute in the School of Medicine
2001 School of Medicine
Education
Ph.D. 1998
1998 Harvard University
Post-Doct Fellow, Biological Chemistry
2001 Harvard University
Publications, Grants & Awards
- Grants (33)
- Academics Articles (141)
- Conference Pages (11)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Science Foundation
Rensselaer Polytechnic Institute
National Institutes of Health
University of South Alabama
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
D5 Therapeutics, Inc
Valanbio Therapeutics, Inc.
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Medical University of South Carolina
National Institutes of Health
National Institutes of Health
National Institutes of Health
North Carolina Biotechnology Center
National Institutes of Health
National Institutes of Health
North Carolina Biotechnology Center
North Carolina Biotechnology Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Journal of Structural Biology: X
Sci Transl Med
Chemmedchem
Current Opinion in Plant Biology
Nature Communications
Nar Cancer
Cell Death & Disease
Antimicrob Agents Chemother
Computational and Structural Biotechnology Journal
Biochemical and Biophysical Research Communications
The Journal of Biological Chemistry
Nature Communications
Nature Communications
Cell Death & Disease
Frontiers in Molecular Biosciences
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Nature Metabolism
Proc Natl Acad Sci U S A
Nature Communications
Acs Infectious Diseases
Nature Communications
Frontiers in Cellular and Infection Microbiology
Nature Communications
Biochimica Et Biophysica Acta (Bba) Molecular and Cell Biology of Lipids
Chem Commun (Camb)
Nat Chem Biol
Journal of Antimicrobial Chemotherapy
Nature Microbiology
Nature Communications
J Org Chem
Nature Communications
Proc Natl Acad Sci U S A
Nucleic Acids Res
The Journal of Biological Chemistry
Proc Natl Acad Sci U S A
Acs Chem Biol
Journal of Medicinal Chemistry
The Journal of Biological Chemistry
Journal of the American Chemical Society
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
The Journal of Biological Chemistry
The Journal of Biological Chemistry
J Biomol Nmr
Science (New York, N.Y.)
The Journal of Biological Chemistry
The Journal of Biological Chemistry
J Magn Reson
Faseb Journal
Biomol Nmr Assign
J Comput Biol
J Comput Biol
The Journal of Biological Chemistry
J Biomol Nmr
Proc Natl Acad Sci U S A
Journal of Biomolecular Nmr
J Magn Reson
The Journal of Biological Chemistry
Bioorg Med Chem
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Chemistry & Biology
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Springer Tracts in Advanced Robotics
Prog Nucl Magn Reson Spectrosc
J Biomol Nmr
J Magn Reson
Biomol Nmr Assign
Molecular Cell
Journal of Biomolecular Nmr
Curr Pharm Biotechnol
Computational Systems Bioinformatics. Computational Systems Bioinformatics Conference
Computational Systems Bioinformatics. Computational Systems Bioinformatics Conference
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
Proc Natl Acad Sci U S A
Genes & Development
Journal of Molecular Biology
The Journal of Biological Chemistry
Biochemistry
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
Journal of Biomolecular Nmr
Journal of Biomolecular Nmr
Proceedings of the National Academy of Sciences of the United States of America
Molecular Cell
Journal of the American Chemical Society
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
Journal of the American Chemical Society
Biochemistry
Journal of the American Chemical Society
Journal of Biomolecular Nmr
Nature Structural Biology
Journal of Biomolecular Nmr
The Journal of Biological Chemistry
Journal of the American Chemical Society
Proceedings of the National Academy of Sciences of the United States of America
Journal of Biomolecular Nmr
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
Abstracts of Papers of the American Chemical Society
Biophysical Journal
Faseb Journal
Faseb Journal
New Developments in NMR
New Developments in NMR
Offices & Contact
Durham, NC
27710 Duke Box 3711
Durham, NC
27710