Qiu Wang
Professor of Chemistry
Overview
Research in the Wang group aims to answer fundamental questions that lie at the interface of chemistry and biology. In particular, we are interested in developing small-molecule based probes and methods to understand the cause of disease with an emphasis on identifying potential therapeutic agents towards cancer and neurodegenerative disorders.
- Bioactive molecules as probes in human biology and disease. Starting from naturally occurring molecules that possess unique anti-cancer activity or neuroprotective/neurotrophic activities, our research incorporates synthetic chemistry and biological efforts to expedite discovery of novel bioactive molecules and to facilitate the study of their biological properties. Chemistry efforts will emphasize the development of modular approaches to target molecules and new methodologies to maximize synthetic efficiency. Biological studies will focus on profiling the activities of selected compounds and identifying their mode of action.
- Epigenetic modifying enzymes as novel therapeutic targets. We are interested in developing small-molecule regulators of epigenetics modifications, the new frontier in understanding and treatment of disease. For example, research will be directed towards identifying small-molecule modulators of arginine methylation and uncovering their regulatory pathways. Discovery of such molecules will provide powerful tools to interrogate the physiological roles of arginine methylation and offer potential lead molecules for novel therapies to contribute to a new era of epigenetic-based drugs.
- New chemical tools for biomolecule labeling and target identification. Our research also involves the development of new chemical tools to enable selective detection of the temporal and spatial small-molecule ligand-biomolecule interactions in vitro and in vivo. Towards this end, we will design and synthesize photoaffinity cross-linking tools to label methyltransferases, their substrates, and their binding partners.
Overall, the research in the Wang group involves the interplay of these three complementary areas and integrates the principles of synthetic chemistry, assay development, molecular and cell biology, genetics, and proteomics. Through this interdisciplinary approach, we will create a small-molecule toolbox for studying genes and pathways of importance to cancer and neurodegenerative disorders.
Positions
Professor of Chemistry in the Trinity College of Arts & Sciences
2023 Trinity College of Arts & Sciences
Faculty Network Member of the Duke Institute for Brain Sciences in the Institutes and Provost's Academic Units
2014 Institutes and Provost's Academic Units
Member of the Duke Cancer Institute in the School of Medicine
2015 School of Medicine
Education
B.S. 1999
1999 Wuhan University (China)
Ph.D. 2005
2005 Emory University
Postdoctoral Research Associate, Chemistry
2007 Harvard University
Postdoctoral Research Associate, Chemistry
2011 Harvard University
Publications, Grants & Awards
- Grants (18)
- Academics Articles (65)
- Book Sections (2)
National Institutes of Health
National Science Foundation
National Science Foundation
National Institutes of Health
American Chemical Society
American Chemical Society
National Science Foundation
National Institutes of Health
Camille & Henry Dreyfus Foundation, Inc.
Alfred P. Sloan Foundation
National Institutes of Health
Department of Education
National Institutes of Health
National Science Foundation
National Institutes of Health
University of Florida
Michael J. Fox Foundation for Parkinson's Research
American Chemical Society
Journal of the American Chemical Society
Bioorganic & Medicinal Chemistry
Chemistry, an Asian Journal
Angewandte Chemie International Edition
Chem. Sci.
Acs Catalysis
Journal of Medicinal Chemistry
Acs Catalysis
Acs Medicinal Chemistry Letters
Bioconjugate Chemistry
Organic Letters
The Journal of Organic Chemistry
Angewandte Chemie International Edition
Science Advances
Angewandte Chemie
Angewandte Chemie International Edition
Angewandte Chemie International Edition
Journal of the American Chemical Society
Journal of the American Chemical Society
Journal of the American Chemical Society
Organic Letters
The Journal of Physical Chemistry C
The Journal of Organic Chemistry
Organic Letters
Journal of the American Chemical Society
Science Advances
Organic Chemistry Frontiers
Beilstein Journal of Organic Chemistry
Organic Letters
The Journal of Organic Chemistry
Organic Syntheses; an Annual Publication of Satisfactory Methods for the Preparation of Organic Chemicals
Synlett
Cancer Discovery
Angewandte Chemie International Edition
Nature Communications
Chemical Communications
Angewandte Chemie International Edition
The Journal of Organic Chemistry
Cell Death & Disease
Organic Letters
Acs Chemical Biology
Bioorganic & Medicinal Chemistry Letters
The Journal of Organic Chemistry
The Journal of Organic Chemistry
Organic Letters
Tetrahedron Letters
The Journal of Organic Chemistry
Organic Letters
Organic Letters
The Journal of Organic Chemistry
The Journal of Organic Chemistry
COPPER-CATALYZED ELECTROPHILIC AMINATION OF SP2 AND SP3 C-H BONDS
Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
Offices & Contact
Durham, NC
27705 Box 90346, 124 Science Drive
Durham, NC
27705