Rebecca Buckley
James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine
Overview
The overall emphasis of Dr. Buckley's research is in human T,B and NK cell development and in aberrations in their development and regulation. The work involves three particular areas of investigation: 1) the cellular and molecular bases of genetically-determined human immunodeficiency diseases, 2) the use of bone marrow stem cells to cure genetically-determined immunodeficiency diseases, and 3) the use of human SCID bone marrow stem cell chimeras to study human thymic education, T and B cell ontogeny, tolerance induction and MHC restriction mechanisms. Methodology includes monoclonal antibody (mAb) analyses of lymphocyte phenotypes, a variety of T cell and natural killer (NK) cell functional assays, studies of thymic output by T cell receptor recombination excision circle measurement, studies of T cell diversity by spectratyping, studies of T cell longevity by telomere analysis and assessment of B cell differentiation and function. A unique resource available for her studies is the largest population of patients with genetically-determined immunodeficiency diseases in the U.S., which includes the largest population in the world of longterm SCID chimeras treated at a single center, some of whom have been studied and followed for more than 37 years. The administration of rigorously T cell depleted haploidentical bone marrow stem cells to SCID recipients without pre-transplant conditioning or post-transplant use of immunosuppressive drugs to prevent GVHD provides an unmanipulated system for studying human thymic education, T and B cell ontogeny, MHC restriction mechanisms and tolerance induction. Studies to identify mutations in patients with primary immunodeficiency are continuing, particularly in those with SCID.
Positions
James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine in the School of Medicine
2022 School of Medicine
Professor Emeritus of Pediatrics in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1965 School of Medicine
Education
M.D. 1958
1958 University of North Carolina - Chapel Hill
Publications, Grants & Awards
- Grants (29)
- Awards (6)
- Academics Articles (389)
- Conference Pages (117)
- Book Sections (1)
Carolinas HealthCare System
National Institutes of Health
Baxter Healthcare Corporation
University of California - San Francisco
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of North Carolina
American Association of Immunologists
American Pediatric Society
National Academy of Science
American Society for Microbiology
Institute of Medicine of The National Academies
The Journal of Allergy and Clinical Immunology
J Clin Immunol
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
J Allergy Clin Immunol Pract
J Allergy Clin Immunol Pract
The New England Journal of Medicine
J Clin Immunol
J Clin Immunol
J Clin Immunol
Frontiers in Immunology
Journal of Allergy and Clinical Immunology
J Clin Immunol
The Journal of Allergy and Clinical Immunology
North Carolina Medical Journal
The Journal of Allergy and Clinical Immunology
Ann Rheum Dis
The Journal of Allergy and Clinical Immunology
Frontiers in Immunology
The Journal of Allergy and Clinical Immunology
J Allergy Clin Immunol Pract
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Pediatr Radiol
Mlo: Medical Laboratory Observer
Pediatr Blood Cancer
J Clin Immunol
Pediatr Blood Cancer
The Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
The New England Journal of Medicine
The Journal of Allergy and Clinical Immunology
J Allergy Clin Immunol Pract
J Allergy Clin Immunol Pract
The Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
The New England Journal of Medicine
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
Frontiers in Immunology
Bone Marrow Transplant
Journal of Clinical Immunology
The Journal of Allergy and Clinical Immunology
Bone Marrow Transplantation
J Clin Immunol
Proc Natl Acad Sci U S A
The Journal of Allergy and Clinical Immunology
Journal of Clinical Immunology
Immunol Res
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
The Journal of Allergy and Clinical Immunology
Clinical and Experimental Immunology
Pharmaceuticals Policy and Law
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Immunology (Orlando, Fla.)
Journal of Pediatric Hematology/Oncology
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
The Journal of Clinical Investigation
The Journal of Clinical Investigation
The Journal of Immunology
Molecular Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Immunology (Orlando, Fla.)
Annual Review of Immunology
Paediatric Respiratory Reviews
Genetics in Medicine : Official Journal of the American College of Medical Genetics
International Immunopharmacology
Vox Sanguinis
The Journal of Immunology
Lancet (London, England)
Journal of Allergy and Clinical Immunology
Lancet (London, England)
Current Allergy and Asthma Reports
Immunological Reviews
Blood Cells, Molecules, and Diseases
Journal of Allergy and Clinical Immunology
Faseb Journal
Pediatric Research
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Molecular Cell
Ajr. American Journal of Roentgenology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Reviews in Allergy & Immunology
Pediatric Dermatology
Clinical Immunology (Orlando, Fla.)
The New England Journal of Medicine
American Journal of Human Genetics
Nature Medicine
The New England Journal of Medicine
Human Gene Therapy
Faseb Journal
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Immunologic Research
Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
Cancer Research Therapy and Control
American Journal of Human Genetics
The New England Journal of Medicine
Faseb Journal
The New England Journal of Medicine
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
American Journal of Medical Genetics
Faseb Journal
Faseb Journal
Leukemia Research
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
The Journal of Pediatrics
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
The Journal of Pediatrics
Journal of Clinical Immunology
The Journal of Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Pediatric Asthma, Allergy & Immunology
Journal of Clinical Immunology
Pediatric Dermatology
The New England Journal of Medicine
The American Journal of Surgical Pathology
Faseb Journal
Faseb Journal
Pediatric Research
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
The Journal of Pediatrics
Science (New York, N.Y.)
American Journal of Human Genetics
American Journal of Human Genetics
American Journal of Human Genetics
Faseb Journal
Faseb Journal
Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
The New England Journal of Medicine
The Journal of Clinical Investigation
Pediatric Clinics of North America
Biochimica Et Biophysica Acta
The New England Journal of Medicine
Pediatric Research
Faseb Journal
Seminars in Hematology
Clinical Research
Seminars in Hematology
Cellular Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Immunology and Immunopathology
The New England Journal of Medicine
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
The New England Journal of Medicine
The Journal of Clinical Investigation
The New England Journal of Medicine
The Journal of Immunology
Journal of Clinical Immunology
Journal of Immunological Methods
The Journal of Immunology
Pediatric Asthma, Allergy & Immunology
The Journal of Pediatrics
Clinical and Experimental Immunology
Annals of Internal Medicine
Pediatric Asthma, Allergy & Immunology
Jama
Journal of Clinical Immunology
Pediatric Infectious Disease Journal
Clinical and Experimental Immunology
The Journal of Immunology
The Journal of Immunology
The New England Journal of Medicine
Federation Proceedings
Federation Proceedings
Pediatric Asthma, Allergy & Immunology
The American Journal of Medicine
Journal of Clinical Immunology
The New England Journal of Medicine
The New England Journal of Medicine
The New England Journal of Medicine
The New England Journal of Medicine
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Journal of Allergy and Clinical Immunology
Clinical and Experimental Immunology
Journal of Allergy and Clinical Immunology
The Journal of Immunology
Clinical Research
Pediatric Research
Pediatric Research
Clinical Research
The New England Journal of Medicine
The Journal of Pediatrics
Journal of Clinical Immunology
The New England Journal of Medicine
Archives of Internal Medicine
Clinical Immunology and Immunopathology
Annals of Internal Medicine
Clinical Research
Journal of Allergy and Clinical Immunology
Pediatric Research
Clinics in Immunology and Allergy
Federation Proceedings
Federation Proceedings
Clinics in Immunology and Allergy
Pediatric Research
Clinical and Experimental Immunology
Clinical Immunology and Immunopathology
International Archives of Allergy and Applied Immunology
The Journal of Pediatrics
Journal of Allergy and Clinical Immunology
Clinical Immunology and Immunopathology
Federation Proceedings
Clinical Research
Journal of Allergy and Clinical Immunology
Jama
Journal of Allergy and Clinical Immunology
The Journal of Immunology
Federation Proceedings
Jama
Birth Defects Original Article Series
Birth Defects Original Article Series
Birth Defects Original Article Series
Birth Defects Original Article Series
Jama
Annals of Allergy
The Journal of Pediatrics
Clinical and Experimental Immunology
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Federation Proceedings
Clinical Immunology and Immunopathology
The Journal of Pediatrics
The Journal of Immunology
The American Journal of Medicine
Federation Proceedings
Federation Proceedings
Pediatric Research
The Journal of Pediatrics
Pediatric Research
Clinical Research
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Lancet (London, England)
The Histochemical Journal
Lancet (London, England)
Journal of Allergy and Clinical Immunology
The Journal of Pediatrics
Federation Proceedings
The Journal of Immunology
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Journal of Allergy and Clinical Immunology
Pediatric Research
Drug Therapy
Journal of Allergy and Clinical Immunology
Pediatric Nursing
Pediatric Nursing
Pediatric Research
The Journal of Immunology
The Journal of Pediatrics
Journal of Allergy and Clinical Immunology
Federation Proceedings
The Journal of Clinical Investigation
Immunological Reviews
Clinical Immunology and Immunopathology
Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
Clinical Immunology and Immunopathology
Pediatric Clinics of North America
Clinical Research
Clinical Research
Journal of Allergy and Clinical Immunology
National Cancer Institute Monograph
The Journal of Pediatrics
Journal of Investigative Dermatology
The Journal of Clinical Investigation
The New England Journal of Medicine
Journal of Allergy and Clinical Immunology
Pediatric Research
Clinical Immunology and Immunopathology
Cellular Immunology
Journal of Allergy and Clinical Immunology
The Journal of Pediatrics
Lancet (London, England)
The Journal of Pediatrics
The Journal of Immunology
Pediatric Research
Clinical Research
Clinical Research
Pediatric Research
Journal of Allergy and Clinical Immunology
The Journal of Clinical Investigation
Birth Defects Original Article Series
Birth Defects Original Article Series
Birth Defects Original Article Series
Clinical and Experimental Immunology
Biochemical and Biophysical Research Communications
The Journal of Immunology
Journal of Allergy and Clinical Immunology
American Journal of Diseases of Children (1960)
The Journal of Immunology
The New England Journal of Medicine
Clinical and Experimental Immunology
American Journal of Obstetrics and Gynecology
The New England Journal of Medicine
The New England Journal of Medicine
The Journal of Pediatrics
The New England Journal of Medicine
Pediatrics
Pediatric Research
Clinical and Experimental Immunology
Journal of Allergy
International Archives of Allergy and Applied Immunology
The Journal of Pediatrics
International Archives of Allergy and Immunology
Journal of Allergy
Clinical Immunology (Orlando, Fla.)
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Allergy and Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Journal of Clinical Immunology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
J Clin Immunol
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Human Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
INTRAVENOUS IMMUNOGLOBULINS IN THE THIRD MILLENNIUM
Molecular Therapy
American Journal of Human Genetics
Blood Cells, Molecules, and Diseases
American Journal of Human Genetics
Molecular Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
International Congress Series
International Congress Series
Pediatric Research
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Seminars in Hematology
The Journal of Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
PROGRESS IN ALLERGY AND CLINICAL IMMUNOLOGY, VOL 2, KYOTO
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Research
PROGRESS IN IMMUNE DEFICIENCY III
EXPERIMENTAL HEMATOLOGY TODAY - 1989
PROGRESS IN ALLERGY AND CLINICAL IMMUNOLOGY
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Clinical Research
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Pediatric Research
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
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Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
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Journal of Allergy and Clinical Immunology
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Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Annals of Allergy
Journal of Allergy and Clinical Immunology
Federation Proceedings
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Pediatric Research
Federation Proceedings
Journal of Allergy
Pediatric Research
Journal of Allergy
Journal of Allergy
Southern Medical Journal
Southern Medical Journal
Journal of Allergy
Journal of Allergy
Federation Proceedings
Middleton's Allergy: Principles and Practice: Eighth Edition
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