Rodger Alan Liddle
Professor of MedicineOverview
Our laboratory has two major research interests:
Enteroendocrine Cell Biology
Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body. They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood. Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating. Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain. Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety. We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’. Our laboratory is devoted to understanding EECs signaling and its role in disease.
Pancreatitis
Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes. Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis.
Positions
Professor of Medicine in the School of Medicine
1994 School of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences in the University Institutes and Centers
2013 University Institutes and Centers
Member of the Duke Cancer Institute in the School of Medicine
1988 School of Medicine
Education
B.S. 1972
1972 University of Utah
M.D. 1978
1978 Vanderbilt University
Internship, GENERAL INTERNAL MEDICINE
1979 University of California, San Francisco
Residency, GENERALINTERNAL MEDICINE
1981 University of California, San Francisco
Gastroenterology Fellowship, GASTROENTEROLOGY
1984 University of California, San Francisco
Publications, Grants & Awards
Offices & Contact
Durham, NC
27710 Duke Box 103859
Durham, NC
27710