Rodger Liddle
Professor of Medicine
Overview
Our laboratory has two major research interests:
Enteroendocrine Cell Biology
Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body. They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood. Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating. Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain. Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety. We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’. Our laboratory is devoted to understanding EECs signaling and its role in disease.
Pancreatitis
Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes. Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis.
Positions
Professor of Medicine in the School of Medicine
1994 School of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences in the Institutes and Provost's Academic Units
2013 Institutes and Provost's Academic Units
Member of the Duke Cancer Institute in the School of Medicine
1988 School of Medicine
Education
B.S. 1972
1972 University of Utah
M.D. 1978
1978 Vanderbilt University
Internship, General Internal Medicine
1979 University of California - San Francisco
Residency, Generalinternal Medicine
1981 University of California - San Francisco
Gastroenterology Fellowship, Gastroenterology
1984 University of California - San Francisco
Publications, Grants & Awards
- Grants (42)
- Academics Articles (229)
- Conference Pages (23)
- Book Sections (4)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Michael J. Fox Foundation for Parkinson's Research
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Carnegie Institution of Washington
National Pancreas Foundation
National Institutes of Health
Pew Scholars Program
National Institutes of Health
National Institutes of Health
National Institutes of Health
Durham Veterans Affairs Medical Center
National Institutes of Health
Durham Veterans Affairs Medical Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Biocryst Corporation
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Veterans Administration Medical Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Pancreas
Am J Physiol Gastrointest Liver Physiol
Am J Physiol Gastrointest Liver Physiol
Jci Insight
Gastroenterology
Acta Neuropathol
Cell Host Microbe
J Clin Invest
The Journal of Biological Chemistry
Function (Oxf)
J Clin Invest
Cellular and Molecular Gastroenterology and Hepatology
Brain Res
Comprehensive Physiology
Nature Communications
Current Opinion in Gastroenterology
Curr Opin Endocrinol Diabetes Obes
The Political Quarterly
The Political Quarterly
Cellular and Molecular Gastroenterology and Hepatology
The Political Quarterly
Scientific Reports
Pancreatology
Journal of Visualized Experiments : Jove
J Clin Invest
The Political Quarterly
Cellular and Molecular Gastroenterology and Hepatology
Curr Opin Gastroenterol
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Curr Opin Gastroenterol
J Clin Invest
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jop : Journal of the Pancreas
Curr Opin Gastroenterol
Gastroenterology
Am J Physiol Gastrointest Liver Physiol
J Cancer Epidemiol
Clinical and Translational Science
Curr Opin Gastroenterol
Pancreas
Am J Physiol Gastrointest Liver Physiol
Gastroenterology
Am J Physiol Gastrointest Liver Physiol
Curr Opin Gastroenterol
Gut
Archives of General Psychiatry
Biochimica Et Biophysica Acta
Curr Opin Endocrinol Diabetes Obes
Gastroenterology
American Journal of Physiology Gastrointestinal and Liver Physiology
Endocrinology and Metabolism Clinics of North America
Pancreas
Gastroenterology
Current Opinion in Gastroenterology
Gastroenterology
Digestive Diseases and Sciences
Gastroenterology Clinics of North America
Gastroenterology
Diagnostic Microbiology and Infectious Disease
American Journal of Physiology Gastrointestinal and Liver Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]
Gastroenterology
Gastroenterology
Nutrition
Current Opinion in Endocrinology & Diabetes
American Journal of Physiology Gastrointestinal and Liver Physiology
Current Opinion in Gastroenterology
Gastroenterology
American Journal of Physiology Gastrointestinal and Liver Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
Gastroenterology
Gastroenterology
Journal of Gastroenterology
Current Opinion in Gastroenterology
Gastrointestinal Endoscopy
Gastroenterology
Biochemical and Biophysical Research Communications
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
Proceedings of the National Academy of Sciences of the United States of America
Am J Physiol Regul Integr Comp Physiol
Clinical Chemistry
Gastroenterology
Regulatory Peptides
Clinical Therapeutics
The American Journal of Physiology
Endocrinology
Am J Physiol Gastrointest Liver Physiol
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
American Journal of Clinical Nutrition
Annual Review of Physiology
Current Opinion in Gastroenterology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
Proceedings of the National Academy of Sciences of the United States of America
American Journal of Physiology Gastrointestinal and Liver Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
The American Journal of Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
The Western Journal of Medicine
Hepatology (Baltimore, Md.)
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
Gastroenterology
Gastroenterology
Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
Biochemical and Biophysical Research Communications
American Journal of Physiology Gastrointestinal and Liver Physiology
The American Journal of Physiology
The Journal of Nutrition
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
The American Journal of Physiology
Peptides
Journal of Protein Chemistry
Biochemical and Biophysical Research Communications
The American Journal of Physiology
The American Journal of Physiology
Journal of Medicinal Chemistry
The American Journal of Physiology
The American Journal of Physiology
Biochemical and Biophysical Research Communications
The Journal of Clinical Endocrinology and Metabolism
The American Journal of Physiology
The American Journal of Physiology
Biochimica Et Biophysica Acta
The American Journal of Psychiatry
Regulatory Peptides
Regulatory Peptides
Proceedings of the National Academy of Sciences of the United States of America
The American Journal of Physiology
The American Journal of Physiology
The Journal of Biological Chemistry
The American Journal of Physiology
The American Journal of Physiology
Gastroenterology
Biological Psychiatry
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Endocrinology and Metabolism
Clinical Research
Clinical Research
The American Journal of Physiology
The American Journal of Physiology
Gastroenterology
The American Journal of Physiology
The American Journal of Physiology
Gastroenterology Clinics of North America
The American Journal of Physiology
The Journal of Clinical Investigation
Archives of Internal Medicine
The American Journal of Physiology
The American Journal of Physiology
The American Journal of Physiology
Clinical Research
The American Journal of Physiology
The American Journal of Physiology
The New England Journal of Medicine
The New England Journal of Medicine
The American Journal of Physiology
The American Journal of Physiology
The American Journal of Physiology
The American Journal of Physiology
The American Journal of Physiology
Psychopharmacology Bulletin
The American Journal of Physiology
The American Journal of Physiology
The New England Journal of Medicine
The Journal of Clinical Investigation
The Journal of Clinical Investigation
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Investigation
The American Journal of Physiology
The American Journal of Physiology
The Journal of Clinical Investigation
Advances in Experimental Medicine and Biology
The Journal of Clinical Investigation
Gastroenterology
Molecular and Cellular Biochemistry
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology
Pancreas
American Journal of Gastroenterology
Acta Physiologica
Gastroenterology
Gastroenterology
Gastroenterology
Gastroenterology
Gastroenterology
Gastroenterology
Faseb Journal
Gastroenterology
Gastroenterology
Gastroenterology
Gastroenterology
The Journal of Nutrition
Gastroenterology
Physiology of the Gastrointestinal Tract, Sixth Edition
Physiology of the Gastrointestinal Tract, Two Volume Set
Towards a Social Investment Welfare State?: Ideas, Policies and Challenges
Sleisenger and Fordtran’s Gastrointestinal and Liver Disease- 2 Volume Set: Pathophysiology, Diagnosis, Management, Expert Consult Premium Edition - Enhanced Online Features and Print
Offices & Contact
Durham, NC
27710 Duke Box 103859, 1033A GSRB-1
Durham, NC
27710