Scott Richard Floyd
Scott Richard Floyd

Scott Richard Floyd

Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology

Overview

Diseases of the brain carry particular morbidity and mortality, given the fundamental function of the brain for human life and quality of life. Disease of the brain are also particularly difficult to study, given the complexity of the brain. Model systems that capture this complexity, but still allow for experiments to test therapies and mechanisms of disease are badly needed.  We have developed an experimental model system that uses slices made from rat and mouse brains to create a test platform to research new treatments for brain diseases such as stroke, Alzheimer's disease, Huntington's disease and brain tumors. This model system reduces the number of experimental animals used, and streamlines experiments so that final testing in laboratory animals is more efficient. We use this brainslice system and limited numbers of experimental animals to test drugs and genetic pathways to treat stroke, Alzheimer's disease, Huntington's disease and brain tumors. As many brain tumors are treated with radiation therapy, we have a particular interest in the cellular response to DNA damage caused by radiation. DNA damage signaling and repair are fundamental processes necessary for cells to maintain genomic integrity. Problems with these processes can lead to cancer. As many cancer cells have altered DNA damage and repair pathways, we can apply DNA damage as cancer therapy. Our knowledge of how normal and neoplastic cells handle DNA damage is still incomplete. A deeper understanding can lead to improved cancer treatment, and to better protection from the harmful effects of DNA damaging agents like radiation. To this end, we plan experiments that test the effects of radiation on normal animal tissues and animal models of cancer, as well as molecular pathways in brain diseases such as Alzheimer’s, Huntington’s and stroke.

Positions

Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology in the School of Medicine

2019 School of Medicine

Associate Professor of Radiation Oncology in the School of Medicine

2018 School of Medicine

Assistant Research Professor in Pharmacology and Cancer Biology in the School of Medicine

2016 School of Medicine

Member of the Duke Cancer Institute in the School of Medicine

2015 School of Medicine

Education

M.D. 2002

2002 Yale University, School of Medicine

Ph.D. 2002

2002 Yale University

Intern, INTERNAL MEDICINE

2003 Hospital of Saint Raphael

Resident, HARVARD RADIATION ONCOLOGY PROGRAM

2007 Harvard Medical School

Clinical Investigator, KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH

9999 Massachusetts Institute of Technology

Publications, Grants & Awards

DCI Centers, Cancer Types & Labs

Offices & Contact

Duke Cancer Institute
Durham, NC
27710
Levine Science Research Center, B233
Durham, NC
27710