Xiaoping Zhong
Professor of Pediatrics
Overview
The immune system protects the host from microbial infection but can cause diseases if not properly controlled. My lab is interested in the receptor signaling mediated regulation of immune cell development and function as well as the pathogenesis and treatment of autoimmune diseases and allergies.
We are currently investigating the roles diacylglycerol kinases (DGKs) and TSC1/2-mTOR play in the immune system. DGKs are a family of ten enzymes that catalyze the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), Both DAG and PA are important second messengers involved signaling from numerous receptors. While we expect DGKs to perform important roles in development and cellular function by modulating DAG and PA levels, the physiologic functions of DGKs have been poorly understood. Using cell line models and genetically manipulated mice, we have demonstrated that DGKα and ζ isoforms play critical roles in: T cell development, activation, and anergy by regulating T cell receptor signaling; FcεRI signaling and mast cell function; and Toll-like receptor signaling and innate immune responses.
Research areas that we are actively pursuing include:
1. The mechanisms that control T cell maturation, activation
and self-tolerance.
2. NKT cell development and function.
3. Thymic epithelial cells and thymic development, function, and involution.
4. Regulation of Toll-like receptor signaling and innate immunity.
5. The pathogenesis and treatment of autoimmune hepatitis.
6. Mast cell development and function.
7. The pathogenesis and immunotherapy for peanut allergy.
Positions
Professor of Pediatrics in the School of Medicine
2016 School of Medicine
Professor of Integrative Immunobiology in the School of Medicine
2017 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2004 School of Medicine
Education
M.D. 1985
1985 First Medical College in Guangzhou (China)
Ph.D. 1997
1997 Duke University
Publications, Grants & Awards
- Grants (18)
- Academics Articles (108)
- Conference Pages (8)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Journal of Translational Medicine
Journal of Cancer
Frontiers in Genetics
Frontiers in Immunology
Journal of the American Heart Association
Nature Communications
Frontiers in Immunology
Frontiers in Immunology
Frontiers in Immunology
Life Sci
Eur J Immunol
Exp Cell Res
The Embo Journal
Immunohorizons
Cell Death & Disease
Journal of Cancer
Journal of Cancer
Frontiers in Immunology
Frontiers in Immunology
Frontiers in Immunology
Frontiers in Immunology
Frontiers in Immunology
Frontiers in Immunology
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Scientific Reports
Bmc Biochemistry
J Clin Immunol
Frontiers in Cell and Developmental Biology
Nature Communications
Proc Natl Acad Sci U S A
The Journal of Biological Chemistry
Mol Nutr Food Res
Eur J Immunol
Critical Reviews in Immunology
Frontiers in Immunology
Molecular and Cellular Biology
The Journal of Allergy and Clinical Immunology
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Arch Immunol Ther Exp (Warsz)
J Immunol
Food and Agricultural Immunology
J Immunol
The Journal of Immunology
Aip Conference Proceedings
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
The Embo Journal
Molecular Biology of the Cell
Proc Natl Acad Sci U S A
The Journal of Experimental Medicine
Ernst Schering Found Symp Proc
The Journal of Experimental Medicine
The Journal of Immunology
Nature Immunology
Immunologic Research
The Journal of Biological Chemistry
Immunologic Research
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Immunology
Immunological Reviews
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Experimental Medicine
J Clin Cell Immunol
Crit Rev Immunol
European Journal of Immunology
The Journal of Immunology
Journal of Allergy and Clinical Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
Offices & Contact
Durham, NC
27710 Rm 133 MSRB, Research Drive
Durham, NC
27710