Yuan Zhuang
Professor of Integrative Immunobiology
Overview
Research in our laboratory focuses on molecular mechanism of lymphocyte development and genetic basis of lymphoid diseases such as leukemia and autoimmune disorders. We are using mouse models to investigate the role of E2A and other related transcription factors in lymphocyte development and immune function. We have shown that E2A plays an essential role in regulating both B and T cell development. Mice deficient for E2A cannot produce any B cell and exhibit high incidence of T cell leukemia. Separate studies also indicated that E2A is involved in the development of autoimmune disorders. Our current and future studies are to combine genetic, molecular biology, and immunology means to determine gene expression programs during lymphocyte development.
The mechanistic studies of gene function in animal models provide important clues in understanding relevant human diseases. It has been shown that about 20-30% of pediatric acute lymphocytic leukemias (ALL) are linked to chromosomal rearrangements at the E2A gene locus. Most of these genetic defects produce oncogenic forms of E2A proteins, which are the possible cause of leukemia. The use of animal models allows us to further define the molecular events underlying the disease development. Our long term goal is to provide molecular basis for early diagnosis and treatment of relevant lymphoid system diseases.
Laboratory website: Http://sites.duke.edu/zhuanglab.
Positions
Professor of Integrative Immunobiology in the School of Medicine
2011 School of Medicine
Professor of Molecular Genetics and Microbiology in the School of Medicine
2011 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1995 School of Medicine
Education
Ph.D. 1989
1989 Yale University
Publications, Grants & Awards
- Grants (15)
- Awards (6)
- Academics Articles (136)
- Conference Pages (9)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Cancer Institute
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Association for the Advancement of Science
Leukemia Society of America (Leulemia and Lymphoma Society)
Duke University
Leukemia Society of America (Leulemia and Lymphoma Society)
Leukemia Research Institute
Damon Runyon-Walter Winchell Cancer Fund
Int J Radiat Oncol Biol Phys
World Journal of Gastroenterology
Frontiers in Immunology
Nature Communications
Proc Natl Acad Sci U S A
J Cell Physiol
Frontiers in Genetics
Technology in Cancer Research & Treatment
J Exp Med
Molecular Cancer
J Proteome Res
Cancer Management and Research
Frontiers in Oncology
Journal of Cancer
International Journal of Biological Sciences
Frontiers in Immunology
Proc Natl Acad Sci U S A
Cell Reports
J Exp Med
Scientific Reports
Cancer Discov
Proc Natl Acad Sci U S A
International Journal of Biological Sciences
J Immunol
Critical Reviews in Immunology
Curr Top Dev Biol
Dis Model Mech
Transgenic Research
Curr Biol
Genesis
Immunity
Hum Mol Genet
Nat Immunol
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Dev Dyn
Bmc Developmental Biology
Bmc Developmental Biology
Proc Natl Acad Sci U S A
Advances in Experimental Medicine and Biology
European Journal of Immunology
Proc Natl Acad Sci U S A
Nucleic Acids Res
Faseb Journal
Developmental Cell
The Embo Journal
The Journal of Immunology
Development (Cambridge, England)
The Journal of Immunology
The Journal of Biological Chemistry
Molecular and Cellular Biology
Developmental Biology
Trends in Immunology
Genesis (New York, N.Y. : 2000)
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Molecular Immunology
The Journal of Biological Chemistry
Seminars in Immunology
Proceedings of the National Academy of Sciences of the United States of America
Molecular and Cellular Biology
Transplantation
The Journal of Immunology
Molecular and Cellular Biology
Faseb Journal
Immunologic Research
Nature
The Journal of Immunology
Molecular and Cellular Biology
Molecular and Cellular Biology
Cold Spring Harbor Symposia on Quantitative Biology
Molecular and Cellular Biology
Molecular and Cellular Biology
Molecular Endocrinology (Baltimore, Md.)
Molecular and Cellular Biology
Genes & Development
Proceedings of the National Academy of Sciences of the United States of America
Science (New York, N.Y.)
Genes & Development
Proceedings of the National Academy of Sciences of the United States of America
Molecular and Cellular Biology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
Journal of Investigative Dermatology
Offices & Contact
Durham, NC
27710 Box 3010 DUMC, 328 Jones Building
Durham, NC
27710